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Mouse IL-18/IL-1F4 ELISA

Catalog #: 7625
54 Citations 2 Reviews Datasheet / COA / SDS
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7625
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Citations (54)
FAQs
Supplemental Products
Reviews (2)
Summary Product Datasheets Preparation and Storage Background Related Research Areas

Mouse IL-18/IL-1F4 ELISA Summary

Sample Type & Volume Required Per Well
Serum (30 uL)
Sensitivity
25 pg/mL
Assay Range
25.6 - 1,000 pg/mL
Cross-reactivity
< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
Interference
No significant interference observed with available related molecules.

Product Summary

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Product Datasheet
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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: IL-18/IL-1F4

Interleukin 18 (IL-18), also known as interferon-gamma-inducing factor (IGIF) and IL-1 gamma, is a cytokine which shares biologic activities with IL-12 and structural similarities with the IL-1 family of proteins. IL-18 was originally cloned from liver cells and has since been shown to be expressed by monocyte/macrophages, osteoblasts and keratinocytes. Caspase-1 (IL-1 beta-converting enzyme) has been implicated in the physiological processing of pro-IL-18 to IL-18. Similarly to IL-12, human IL-18 has been shown to enhance NK cell activity in PBMC cultures. Human IL-18 has also been found to induce the production IFN-gamma and GM-CSF while inhibiting the production of IL-10 by PBMC. On enriched human T cells, human IL-18 can enhance Th1 cytokine production and stimulate cell proliferation via an IL-2-dependent pathway. In the mouse system, IL-18 has been shown to be a costimulatory factor for the activation of Th1, but not Th2, cells. IL-18 was found to selectively enhance the FasL-mediated cytotoxicity of Th1, but not Th0 or Th2, cells. IL-18 has also been shown to induce activated B cells to produce IFN-gamma that inhibits IgE production.

Long Name:
Interleukin 18
Entrez Gene IDs:
3606 (Human); 16173 (Mouse); 29197 (Rat); 397057 (Porcine); 574151 (Primate)
Alternate Names:
Iboctadekin; IFN-gamma-inducing factor; IGIF; IGIFIL-1 gamma; IL18; IL-18; IL-18MGC12320; IL-1F4; IL1F4iboctadekin; IL-1g; Interferon gamma-inducing factor; interleukin 18 (interferon-gamma-inducing factor); Interleukin-1 gamma; interleukin-18

Citations for Mouse IL-18/IL-1F4 ELISA

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

54 Citations: Showing 1 - 10
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  1. Augmented antitumor immune responses of HER2-targeted pyroptotic induction by long-lasting recombinant immunopyroptotins
    Authors: Xing, Y;Zhang, F;Yang, T;Yin, C;Yang, A;Yan, B;Zhao, J;
    Heliyon
    Species: Mouse
    Sample Types: Plasma, Tissue Homogenates
  2. Overexpression of NAG-1/GDF15 prevents hepatic steatosis through inhibiting oxidative stress-mediated dsDNA release and AIM2 inflammasome activation
    Authors: Y Wang, C Chen, J Chen, T Sang, H Peng, X Lin, Q Zhao, S Chen, T Eling, X Wang
    Redox Biology, 2022-04-27;52(0):102322.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  3. PPARalpha contributes to the therapeutic effect of hydrogen gas against sepsis-associated encephalopathy with the regulation to the CREB-BDNF signaling pathway and hippocampal neuron plasticity-related gene expression
    Authors: Y Bai, Q Han, B Dong, H Lin, Y Jiang, X Zhang, H Chen, Y Yu
    Brain research bulletin, 2022-03-30;184(0):56-67.
    Species: Mouse
    Sample Types: Tissue Homogenates
  4. Kakonein restores hyperglycemia-induced macrophage digestion dysfunction through regulation of cathepsin B-dependent NLRP3 inflammasome activation
    Authors: D Lian, L Zhu, Y Yu, X Zhang, Y Lin, J Liu, R Han, Y Guo, D Cai, W Xiao, Y Chen, H He, D Xu, C Zheng, X Wang, Y Huang, Y Chen
    Journal of leukocyte biology, 2022-02-27;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  5. TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage
    Authors: P Xu, C Tao, Y Zhu, G Wang, L Kong, W Li, R Li, J Li, C Zhang, L Wang, X Liu, W Sun, W Hu
    Journal of Neuroinflammation, 2021-08-30;18(1):188.
    Species: Mouse
    Sample Types: Tissue Homogenates
  6. Distinct pro-inflammatory properties of myeloid cell-derived apolipoprotein E2 and E4 in atherosclerosis promotion
    Authors: E Igel, A Haller, PR Wolfkiel, M Orr-Asman, A Jaeschke, DY Hui
    The Journal of Biological Chemistry, 2021-08-21;0(0):101106.
    Species: Mouse
    Sample Types: Plasma
  7. Baicalin relieves Mycoplasma�pneumoniae infection?induced lung injury through regulating microRNA?221 to inhibit the TLR4/NF?&kappaB signaling pathway
    Authors: H Zhang, X Li, J Wang, Q Cheng, Y Shang, G Wang
    Molecular Medicine Reports, 2021-06-10;24(2):.
    Species: Mouse
    Sample Types: BALF
  8. Scopolamine promotes neuroinflammation and delirium-like neuropsychiatric disorder in mice
    Authors: SY Cheon, BN Koo, SY Kim, EH Kam, J Nam, EJ Kim
    Scientific Reports, 2021-04-16;11(1):8376.
    Species: Mouse
    Sample Types: Tissue Homogenates
  9. Exosomal circEhmt1 Released from Hypoxia-Pretreated Pericytes Regulates High Glucose-Induced Microvascular Dysfunction via the NFIA/NLRP3 Pathway
    Authors: L Ye, H Guo, Y Wang, Y Peng, Y Zhang, S Li, M Yang, L Wang
    Oxidative Medicine and Cellular Longevity, 2021-03-18;2021(0):8833098.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  10. Pancreastatin Reduces Alternatively Activated Macrophages, Disrupts the Epithelial Homeostasis and Aggravates Colonic Inflammation. A Descriptive Analysis
    Authors: N Eissa, O Elgazzar, H Hussein, GN Hendy, CN Bernstein, JE Ghia
    Biomedicines, 2021-02-01;9(2):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  11. Roseburia�intestinalis?derived flagellin ameliorates colitis by targeting miR?223?3p?mediated activation of NLRP3 inflammasome and pyroptosis
    Authors: X Wu, S Pan, W Luo, Z Shen, X Meng, M Xiao, B Tan, K Nie, T Tong, X Wang
    Mol Med Rep, 2020-07-23;0(0):.
    Species: Mouse
    Sample Types: Serum
  12. IL-1beta suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury
    Authors: S Xiong, Z Hong, LS Huang, Y Tsukasaki, S Nepal, A Di, M Zhong, W Wu, Z Ye, X Gao, GN Rao, D Mehta, J Rehman, AB Malik
    J. Clin. Invest., 2020-07-01;130(7):3684-3698.
    Species: Mouse
    Sample Types: Serum
  13. Signaling Through Purinergic Receptor P2Y2 Enhances Macrophage IL-1&beta Production
    Authors: G de la Rosa, AI Gómez, MC Baños, P Pelegrín
    Int J Mol Sci, 2020-06-30;21(13):.
    Species: Mouse
    Sample Types: Serum
  14. Activation of ASC Inflammasome Driven by TLR4 Contributes to Host Immunity against Rickettsial Infection
    Authors: C Rumfield, I Hyseni, JW McBride, DH Walker, R Fang
    Infect. Immun., 2020-03-23;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  15. Effect of HBx on inflammation and mitochondrial oxidative stress in mouse hepatocytes
    Authors: LR Ling, DH Zheng, ZY Zhang, WH Xie, YH Huang, ZX Chen, XZ Wang, D Li
    Oncol Lett, 2020-02-17;19(4):2861-2869.
    Species: Mouse
    Sample Types: Serum
  16. Targeting Macrophage Histone H3 Modification as a Leishmania Strategy to Dampen the NF-&kappaB/NLRP3-Mediated Inflammatory Response
    Authors: H Lecoeur, E Prina, T Rosazza, K Kokou, P N'Diaye, N Aulner, H Varet, G Bussotti, Y Xing, G Milon, R Weil, G Meng, GF Späth
    Cell Rep, 2020-02-11;30(6):1870-1882.e4.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  17. Intestinal autophagy links psychosocial stress with gut microbiota to promote inflammatory bowel disease
    Authors: SL Wang, BZ Shao, SB Zhao, X Chang, P Wang, CY Miao, ZS Li, Y Bai
    Cell Death Dis, 2019-09-30;10(6):391.
    Species: Mouse
    Sample Types: Tissue Homogenates
  18. Helicobacter pylori Exploits the NLRC4 Inflammasome to Dampen Host Defenses
    Authors: RP Semper, M Vieth, M Gerhard, R Mejías-Luq
    J. Immunol., 2019-09-11;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  19. cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis
    Authors: R Chen, L Zeng, S Zhu, J Liu, HJ Zeh, G Kroemer, H Wang, TR Billiar, J Jiang, D Tang, R Kang
    Sci Adv, 2019-05-22;5(5):eaav5562.
    Species: Mouse
    Sample Types: Serum
  20. Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes
    Authors: JH Bae, SI Jo, SJ Kim, JM Lee, JH Jeong, JS Kang, NJ Cho, SS Kim, EY Lee, JS Moon
    Cells, 2019-04-08;8(4):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  21. SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury
    Authors: D Kurundkar, AR Kurundkar, NB Bone, EJ Becker, W Liu, B Chacko, V Darley-Usm, JW Zmijewski, VJ Thannickal
    JCI Insight, 2019-01-10;4(1):.
    Species: Mouse
    Sample Types: BALF
  22. MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice
    Authors: AP Perera, R Fernando, T Shinde, R Gundamaraj, B Southam, SS Sohal, AAB Robertson, K Schroder, D Kunde, R Eri
    Sci Rep, 2018-06-05;8(1):8618.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  23. Protective effects of Erigeron breviscapus Hand.- Mazz. (EBHM) extract in retinal neurodegeneration models
    Authors: J Zhu, L Chen, Y Qi, J Feng, L Zhu, Y Bai, H Wu
    Mol. Vis., 2018-04-25;24(0):315-325.
    Species: Rat
    Sample Types: Cell Culture Supernates
  24. Salidroside prevents skin carcinogenesis induced by DMBA/TPA in a mouse model through suppression of inflammation and promotion of apoptosis
    Authors: YH Kong, SP Xu
    Oncol. Rep., 2018-04-18;0(0):.
    Species: Mouse
    Sample Types: Serum
  25. Carnosic acid protects mice from high-fat diet-induced NAFLD by regulating MARCKS
    Authors: HM Song, X Li, YY Liu, WP Lu, ZH Cui, L Zhou, D Yao, HM Zhang
    Int. J. Mol. Med., 2018-03-27;0(0):.
    Species: Mouse
    Sample Types: Serum
  26. Juglanin suppresses fibrosis and inflammation response caused by LPS in acute lung injury
    Authors: ZW Dong, YF Yuan
    Int. J. Mol. Med., 2018-03-09;41(6):3353-3365.
    Species: Mouse
    Sample Types: Serum
  27. Hypoxia induced mitogenic factor (HIMF) triggers angiogenesis by increasing interleukin-18 production in myoblasts
    Authors: CM Su, IC Wang, SC Liu, Y Sun, L Jin, SW Wang, HP Lee, WP Tseng, CH Tang
    Sci Rep, 2017-08-07;7(1):7393.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  28. STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection
    Authors: MT Stier, K Goleniewsk, JY Cephus, DC Newcomb, TP Sherrill, KL Boyd, MH Bloodworth, ML Moore, K Chen, JK Kolls, RS Peebles
    J. Immunol., 2017-06-02;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  29. Dipeptidyl peptidase-4 (DPP-4) inhibition with linagliptin reduces western diet-induced myocardial TRAF3IP2 expression, inflammation and fibrosis in female mice
    Authors: AR Aroor, J Habibi, HK Kandikattu, M Garro-Kach, B Barron, D Chen, MR Hayden, A Whaley-Con, SB Bender, T Klein, J Padilla, JR Sowers, B Chandrasek, VG DeMarco
    Cardiovasc Diabetol, 2017-05-05;16(1):61.
    Species: Mouse
    Sample Types: Plasma
  30. Bone marrow produces sufficient alloreactive natural killer (NK) cells in vivo to cure mice from subcutaneously and intravascularly injected 4T1 breast cancer
    Authors: Michel van Gelder
    Breast Cancer Res. Treat, 2016-12-03;0(0):.
    Species: Mouse
    Sample Types: Plasma
  31. Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts
    Authors: Arne Yndestad
    Biochim. Biophys. Acta, 2016-11-12;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  32. Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation
    J Immunol, 2016-08-12;0(0):.
    Species: Mouse
    Sample Types: Plasma
  33. NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence
    Sci Rep, 2016-08-01;6(0):30943.
    Species: Mouse
    Sample Types: BALF
  34. Voluntary Exercise Stabilizes Established Angiotensin II-Dependent Atherosclerosis in Mice through Systemic Anti-Inflammatory Effects.
    Authors: Pellegrin M, Aubert J, Bouzourene K, Amstutz C, Mazzolai L
    PLoS ONE, 2015-11-24;10(11):e0143536.
    Species: Mouse
    Sample Types: Plasma
  35. TLR2 limits development of hepatocellular carcinoma by reducing IL18-mediated immunosuppression.
    Authors: Li S, Sun R, Chen Y, Wei H, Tian Z
    Cancer Res, 2015-01-19;75(6):986-95.
    Species: Mouse
    Sample Types: Serum
  36. A RIPK3-caspase 8 complex mediates atypical pro-IL-1beta processing.
    Authors: Moriwaki K, Bertin J, Gough P, Chan F
    J Immunol, 2015-01-07;194(4):1938-44.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  37. Type I NKT-cell-mediated TNF-alpha is a positive regulator of NLRP3 inflammasome priming.
    Authors: Chow M, Duret H, Andrews D, Faveeuw C, Moller A, Smyth M, Paget C
    Eur J Immunol, 2014-04-29;44(7):2111-20.
    Species: Mouse
    Sample Types: Serum
  38. CD4(+) T cells from food allergy model are resistant to TCR-dependent apoptotic induction.
    Authors: He W, Yang C, Xia L, Zhao M, Ge R, Huang H, Ji Q, Yang P, Liu Z
    Cytokine, 2014-04-16;68(1):32-9.
    Species: Mouse
    Sample Types: Serum
  39. TXNIP deficiency exacerbates endotoxic shock via the induction of excessive nitric oxide synthesis.
    Authors: Park Y, Yoon S, Suh H, Kim D, Park J, Jung H, Kim T, Yoon S, Min J, Na H, Lee S, Lee H, Lee Y, Lee H, Choi I
    PLoS Pathog, 2013-10-03;9(10):e1003646.
    Species: Mouse
    Sample Types: Serum
  40. Impaired bone formation and increased osteoclastogenesis in mice lacking chemokine (C-C motif) ligand 5 (Ccl5).
    Authors: Wintges K, Beil F, Albers J, Jeschke A, Schweizer M, Claass B, Tiegs G, Amling M, Schinke T
    J Bone Miner Res, 2013-10-01;28(10):2070-80.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  41. Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis.
    J. Immunol., 2012-07-11;189(4):1911-9.
    Species: Mouse
    Sample Types: Serum
  42. Modelling of mouse experimental colitis by global property screens: a holistic approach to assess drug effects in inflammatory bowel disease.
    Authors: Gottfries J, Melgar S, Michaelsson E
    PLoS ONE, 2012-01-18;7(1):e30005.
    Species: Mouse
    Sample Types: Tissue Homogenates
  43. The interaction between IL-18 and IL-18 receptor limits the magnitude of protective immunity and enhances pathogenic responses following infection with intracellular bacteria.
    Authors: Ghose P, Ali AQ, Fang R, Forbes D, Ballard B, Ismail N
    J. Immunol., 2011-06-29;187(3):1333-46.
    Species: Mouse
    Sample Types: Serum
  44. Galectin-3 contributes to neonatal hypoxic-ischemic brain injury.
    Authors: Doverhag C, Hedtjarn M, Poirier F, Mallard C, Hagberg H, Karlsson A, Savman K
    Neurobiol. Dis., 2010-01-04;38(1):36-46.
    Species: Mouse
    Sample Types: Tissue Homogenates
  45. T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes.
    Authors: Guarda G, Dostert C, Staehli F, Cabalzar K, Castillo R, Tardivel A, Schneider P, Tschopp J
    Nature, 2009-06-03;460(7252):269-73.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  46. Neutralization of Interleukin-18 Ameliorates Ischemia/Reperfusion-induced Myocardial Injury.
    Authors: Venkatachalam K, Prabhu SD, Reddy VS, Boylston WH, Valente AJ, Chandrasekar B
    J. Biol. Chem., 2009-01-21;284(12):7853-65.
    Species: Mouse
    Sample Types: Tissue Homogenates
  47. Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice.
    Authors: Kang MJ, Lee CG, Lee JY, Dela Cruz CS, Chen ZJ, Enelow R, Elias JA
    J. Clin. Invest., 2008-08-01;118(8):2771-84.
    Species: Mouse
    Sample Types: BALF
  48. Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis.
    Authors: Oku H, Shimizu T, Kawabata T, Nagira M, Hikita I, Ueyama A, Matsushima S, Torii M, Arimura A
    Eur. J. Pharmacol., 2008-06-16;590(1):400-8.
    Species: Mouse
    Sample Types: Tissue Homogenates
  49. Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling.
    Authors: Rosenzweig HL, Martin TM, Planck SR, Galster K, Jann MM, Davey MP, Kobayashi K, Flavell RA, Rosenbaum JT
    J. Leukoc. Biol., 2008-05-21;84(2):529-36.
    Species: Mouse
    Sample Types: Tissue Homogenates
  50. Deletion of TLR5 results in spontaneous colitis in mice.
    Authors: Vijay-Kumar M, Sanders CJ, Taylor RT, Kumar A, Aitken JD, Sitaraman SV, Neish AS, Uematsu S, Akira S, Williams IR, Gewirtz AT
    J. Clin. Invest., 2007-12-01;117(12):3909-21.
    Species: Mouse
    Sample Types: Serum
  51. IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation.
    Authors: Kang MJ, Homer RJ, Gallo A, Lee CG, Crothers KA, Cho SJ, Rochester C, Cain H, Chupp G, Yoon HJ, Elias JA
    J. Immunol., 2007-02-01;178(3):1948-59.
    Species: Mouse
    Sample Types: BALF
  52. IL-1 receptor-associated kinase 1 mediates protection against Staphylococcus aureus infection.
    Authors: Verdrengh M, Thomas JA, Hultgren OH
    Microbes Infect., 2004-11-01;6(14):1268-72.
    Species: Mouse
    Sample Types: Serum
  53. Regulation of Pseudomonas aeruginosa corneal infection in IL-1 beta converting enzyme (ICE, caspase-1) deficient mice.
    Authors: Thakur A, Barrett RP, McClellan S, Hazlett LD
    Curr. Eye Res., 2004-10-01;29(4):225-33.
    Species: Mouse
    Sample Types: Tissue Homogenates
  54. A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection.
    Authors: Harandi AM, Eriksson K, Holmgren J
    J. Virol., 2003-01-01;77(2):953-62.
    Species: Mouse
    Sample Types: Serum

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Mouse IL-18/IL-1F4 ELISA
By Anonymous on 03/15/2023
Sample Tested: Serum
Mouse IL-18/IL-1F4 ELISA 7625
Mouse IL-18/IL-1F4 ELISA
By Sebastien Fauteux on 07/13/2017
Sample Tested: Serum and Plasma

You can shorten the incubation time if expected concentrations are near the maximum limit of the standards.

Reproducible, efficient and recommendable.

Mouse IL-18/IL-1F4 ELISA 7625