Mouse IL-18 R beta /IL-1 R7 Biotinylated Antibody Summary
Phe20-Glu356
Accession # Q9Z2B1
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IL-18 R beta/IL-1 R7
IL-18, originally described as an interferon-gamma inducing factor (IGIF), is a member of the IL-1 family of cytokines that has multiple immunoregulatory functions. It has potent IFN-gamma inducing activities and plays a key role in the activation of T helper type 1 (Th1) responses. The functional IL-18 receptor complex consists of two components, the IL-18R alpha (IL-1 R5) and IL-18R beta (also termed IL-1 R7 and AcPL) subunits. Both subunits are members of the IL-1 receptor superfamily. Although IL-18R alpha by itself binds IL-18 with low-affinity and IL-18R beta does not bind IL-18 in vitro, co-expression of IL-18R alpha and IL-18R beta is required for high-affinity binding and IL-18 responsiveness. Human IL-18R beta cDNA encodes a 599 amino acid (aa) residue precursor type I membrane protein with a aa signal peptide, a aa extracellular region containing three immunoglobulin-like domains, a single transmembrane domain and a 222 aa cytoplasmic domain. Human and mouse IL-18 R beta share 65% aa sequence identity. The expression of IL-18R beta parallels that of IL-18R alpha and is detected in numerous tissues including lung, spleen, leukocytes and colon.
- Born, T.L. et al. (1998) J. Biol. Chem. 273:29445.
- Okamura, H. et al. (2000) in Cytokine Reference, Vol. 2:1605, Academic Press.
Product Datasheets
Citations for Mouse IL-18 R beta /IL-1 R7 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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MCMV triggers ROS/NLRP3-associated inflammasome activation in the inner ear of mice and cultured spiral ganglion neurons, contributing to sensorineural hearing loss
Authors: W Zhuang, C Wang, X Shi, S Qiu, S Zhang, B Xu, M Chen, W Jiang, H Dong, Y Qiao
Int. J. Mol. Med., 2018-03-06;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Constitutive and LPS-regulated expression of interleukin-18 receptor beta variants in the mouse brain
Authors: Silvia Alboni, Claudia Montanari, Cristina Benatti, Johanna M.C. Blom, Maria Luisa Simone, Nicoletta Brunello et al.
Brain, Behavior, and Immunity
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Protection of CD8+ T cells from activation-induced cell death by IL-18.
Authors: Li W, Kashiwamura S, Ueda H, Sekiyama A, Okamura H
J. Leukoc. Biol., 2007-03-30;82(1):142-51.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
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