Mouse Neogenin Biotinylated Antibody Summary
Ala42-Ile1033 with a Asp442-Leu461 deletion
Accession # NP_032710
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Neogenin
Neogenin (NEO) is a type I transmembrane protein that is crucial for axonal guidance and neuronal migration. It is also involved in regulating differentiation programs in many embryonic and adult tissues (1). Mouse NEO is widely expressed in adult tissues and is expressed throughout the mid to late stages of gestation, in both neuronal and non-neuronal tissues. It is a member of the immunoglobulin (Ig) superfamily and is closely related to deleted in colorectal cancer (DCC). Mouse NEO cDNA encodes a 1493 amino acid residue (aa) precursor with a putative 36 aa signal peptide, a 1100 aa extracellular domain with six Ig-like C2 type domains and three fibronectin type III domains, a 21 aa transmembrane domain and a 345 aa cytoplasmic domain. At least five isoforms are produced in mice by alternative splicing. Mouse NEO shares 96%, 93% and 86% aa sequence identity with rat, human and chicken NEO, respectively. It also has 46% and 29% sequence homology with mouse DCC and C. elegans UNC40, a homolog of DCC. NEO and DCC, together with the UNC5 family of type I transmembrane proteins, are receptors for the netrin/UNC6 family of laminin-related bifunctional guidance molecules that both attract some axons and repel others (2, 3). In mouse, at least five netrins (netrin‑1, ‑3, ‑4, G1 and G2) have been identified (3‑5). Mouse netrin-1 and netrin-3 have been shown to be ligands for mouse NEO.
- Keeling, S.L. et al. (1997) Oncogene 15:691.
- Hong, K. et al. (1999) Cell 97:927.
- Livesey, F.J. (1999) Cell Mol. Life Sci. 56:62.
- Nakashiba, T. et al. (2000) J. Neurosci. 20:6540.
- Nakashiba, T. et al. (2002) Mech. Dev. 111:47.
Product Datasheets
Product Specific Notices
This product or the use of this product is covered by U.S. Patents owned by The Regents of the University of California. This product is for research use only and is not to be used for commercial purposes. Use of this product to produce products for sale or for diagnostic, therapeutic or drug discovery purposes is prohibited. In order toobtain a license to use this product for such purposes, contact The Regents of the University of California.U.S. Patent # 5,939,271, 6,277,585, and other U.S. and international patents pending.
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