Mouse OMgp Antibody Summary
Ile25-Ser420
Accession # Q63912
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: OMgp
Oligodendrocyte myelin glycoprotein (OMgp or OMG), Nogo, and myelin-associated glycoprotein (MAG), are three myelin-derived axon outgrowth inhibitors that collapse axonal growth cones and inhibit neurite outgrowth (1 - 3). These three structurally distinct proteins contribute to the myelin-associated inhibitory activity that prevents axonal regeneration after injury of the adult central nervous system (CNS). Mouse OMgp cDNA encodes a 440 amino acid (aa) residue glycosylphosphatidylinositol (GPI)-anchored protein that has a 24 aa signal peptide, eight leucine-rich repeats (LRR) followed by five serine/threonine-rich repeats (4). OMgp has multiple potential N-glycosylation and O-glycosylation sites. Mouse and human OMgp share approximately 88% aa sequence identity. OMgp is expressed on the surface of oligodendrocytes and on large projection neurons, including Purkinje cells of the cerebellum, pyramidal cells of the hippocampus, motoneurons of the brainstem and anterior horn cells of the spinal cord (5). The neurite outgrowth inhibitory activities of all three myelin-derived proteins are mediated by binding to a common receptor complex consisting of the Nogo receptor (NgR) and the p75 neurotrophin receptor (NGFR) (2, 3). Besides its function in the inhibition of axonal growth, OMgp has also been implicated in the inhibition of proliferation. Although the transmembrane receptor that mediates the proliferation inhibition activity has not been identified, the LRR repeats of OMgp were shown to be essential for both the proliferation inhibition and neurite outgrowth inhibition activities (6).
- Kottis, V. et al. (2002) J. Neurochem. 82:1566.
- Wang, K. et al. (2002) Nature 417:941.
- Wang, K. et al. (2002) Nature 420:74.
- Mikol, D.D. et al. (1993) Genomics 17:604.
- Habib, A. et al. (1998) J. Neurochem. 70:1704.
- Vourc’h, P. et al. (2003) J. Neurochem. 85:889.
Product Datasheets
Citations for Mouse OMgp Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Oligodendrocyte myelin glycoprotein does not influence node of ranvier structure or assembly.
Authors: Chang KJ, Susuki K, Dours-Zimmermann MT
J. Neurosci., 2010-10-27;30(43):14476-81.
Species: Mouse
Sample Types: Recombinant Protein, Tissue Homogenates
Applications: Dot Blot, Electron Microscopy, Western Blot -
Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity.
Authors: Raiker SJ, Lee H, Baldwin KT
J. Neurosci., 2010-09-15;30(37):12432-45.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Soluble Nogo receptor down-regulates expression of neuronal Nogo-A to enhance axonal regeneration.
Authors: Peng X, Zhou Z, Hu J, Fink DJ, Mata M
J. Biol. Chem., 2009-11-09;285(4):2783-95.
Species: Rat
Sample Types: Cell Lysates
Applications: Western Blot -
Reassessment of corticospinal tract regeneration in Nogo-deficient mice.
Authors: Lee JK, Chan AF, Luu SM, Zhu Y, Ho C, Tessier-Lavigne M, Zheng B
J. Neurosci., 2009-07-08;29(27):8649-54.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Molecular basis of the interactions of the Nogo-66 receptor and its homolog NgR2 with myelin-associated glycoprotein: development of NgROMNI-Fc, a novel antagonist of CNS myelin inhibition.
Authors: Robak LA, Venkatesh K, Lee H, Raiker SJ, Duan Y, Lee-Osbourne J, Hofer T, Mage RG, Rader C, Giger RJ
J. Neurosci., 2009-05-06;29(18):5768-83.
Species: Rat
Sample Types: Tissue Homogenates
Applications: Western Blot
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