Home / Patched 1/PTCH / Mouse Patched 1/PTCH (NP_032983) VersaClone cDNA

Mouse Patched 1/PTCH (NP_032983) VersaClone cDNA

Catalog #: RDC1109 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
RDC1109
R&D Systems VersaClone cDNA Plasmids
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Mouse Patched 1/PTCH (NP_032983) VersaClone cDNA Summary

Specifications

Source
N/A
Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Mouse

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Background: Patched 1/PTCH

Patched homolog 1 (PTC1) is a 170 - 175 kDa member of the Patched family of proteins. It is found on multiple cells types and forms a constitutive, inactivating complex with Smoothened. Upon SHH binding to PTC1, Smoothened is released and initiates downstream signaling.

Mouse PTC1 is a 12 transmembrane, 1434 aa glycoprotein that contains two terminal cytoplasmic domains. Only one mRNA species for PTC1 has been reported in mice. However, two or more splice forms exist, with variation occurring over the first 150 aa of the N-terminus. Over aa 108 - 422, mouse PTC1 shares 97% and 99% aa sequence identity with human and rat PTC1, respectively.

Entrez Gene IDs
5727 (Human); 19206 (Mouse); 89830 (Rat)
Alternate Names
BCNS; BCNSFLJ42602; FLJ26746; HPE7; mes; NBCCS; patched (Drosophila) homolog; Patched 1; patched homolog (Drosophila); patched homolog 1 (Drosophila); patched homolog 1; protein patched homolog 1; PTC; ptc1; PTCH protein +12b; PTCH protein +4'; PTCH protein -10; PTCH; PTCH1; PTCH11

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