Mouse PIR-B PE-conjugated Antibody Summary
Gly24-Gly635
Accession # AAH26937
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of PIR‑B in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Rat Anti-Mouse B220/CD45R APC-conjugated Monoclonal Antibody (Catalog # FAB1217A) and either (A) Rat Anti-Mouse PIR-B PE-conjugated Monoclonal Antibody (Catalog # FAB2754P) or (B) Rat IgG2APhycoerythrin Isotype Control (Catalog # IC006P). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: PIR-B
Mouse PIR-B is a 125 kDa type I transmembrane glycoprotein with six Ig-like domains in its extracellular domain (ECD) and four ITIM-like sequences in its cytoplasmic domain. The ECD of PIR-B is highly homologous to the ECDs of multiple mouse PIR-A receptors (92-99% amino acid sequence homology), which have short cytoplasmic tails lacking ITIM motifs. PIR-A receptors have a charged residue in their transmembrane domain that facilitates interaction with ITAM-containing adaptor molecules. Whereas PIR-A receptors deliver activation signals, PIR-B can inhibit receptor-mediated activation signaling. PIR-A and PIR-B have been shown to bind various mouse MHC class I molecules. They have been proposed to be orthologs of human leukocyte immunoglobulin-like receptors.
Product Datasheets
Citations for Mouse PIR-B PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 2
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CAMKs support development of acute myeloid leukemia
Authors: X Kang, C Cui, C Wang, G Wu, H Chen, Z Lu, X Chen, L Wang, J Huang, H Geng, M Zhao, Z Chen, M Müschen, HY Wang, CC Zhang
J Hematol Oncol, 2018-02-27;11(1):30.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development.
Authors: Zheng J, Umikawa M, Cui C, Li J, Chen X, Zhang C, Hyunh H, Kang X, Silvany R, Wan X, Ye J, Canto AP, Chen SH, Wang HY, Ward ES, Zhang CC
Nature, 2012-05-30;485(7400):656-60.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
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Naive C57Bl/6 splenocytes were stained with anti-PirB.
