Mouse PRDC/GREM2 Antibody Summary
Arg22-Gln168
Accession # O88273
Applications
Mouse PRDC Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: PRDC/GREM2
PRDC (protein related to DAN and Cerberus) is a secreted cysteine knot-containing BMP antagonist belonging to the Cerberus/DAN (CAN) family. Mammalian CAN family members, including Gremlin, Dan, Cerberus, COCO, SOST, and USAG-1, have the conserved 6 cysteine residues that form a cysteine knot, and two additional cysteine residues located in the loops of the cysteine knot, which form an additional intrasubunit disulfide bond (1, 2). Some members of this family, including PRDC, have an additional cysteine residue used for dimerization (1, 2). Of all the CAN family members, PRDC is most closely related to Gremlin, displaying 52% amino acid sequence identity. PRDC was first identified in a screen for developmentally regulated genes by gene trapping in embryonic stem cells (3). PRDC expression is detected by in situ hybridization in the dorsal edge of the spinal cord at E10.5, in commissural neurons in the caudal part of the spinal cord two days later (3), and in the granulosa cells of selective ovarian follicles (4). In the adult, abundant levels of PRDC are detected by RT-PCR in the mouse ovary, brain, and spleen, and to a lesser degree in the colon, kidney, lung, liver, and uterus (4). PRDC acts as a specific BMP antagonist, binding to and blocking signaling induced by BMP-2 or -4, but not Activin or TGF-beta (4). Thus, PRDC expression in the ovary could be involved in follicular development by antagonizing the inhibitory effects of BMPs on FSH stimulation of progesterone (4).
- Pearce, J. et al. (1999) Dev. Biol. 209:99.
- Avsian-Kretchmer, O. and A. Hsueh (2004) Molecular Endocrinology 18:1.
- Minabe-Saegusa, C. et al. (1998) Develop. Growth Differ. 40:343.
- Sudo, S. et al. (2004) Jour. Biol. Chem. 279:23134.
Product Datasheets
Citations for Mouse PRDC/GREM2 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Unveiling the transcriptomic landscape and the potential antagonist feedback mechanisms of TGF-beta superfamily signaling module in bone and osteoporosis
Authors: Ying-Wen Wang, Wen-Yu Lin, Fang-Ju Wu, Ching-Wei Luo
Cell Communication and Signaling
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Coordinated Proliferation and Differentiation of Human-Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells Depend on Bone Morphogenetic Protein Signaling Regulation by GREMLIN 2
Authors: Jeffery B. Bylund, Linh T. Trinh, Cassandra P. Awgulewitsch, David T. Paik, Christopher Jetter, Rajneesh Jha et al.
Stem Cells and Development
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Members of the DAN Family Are BMP Antagonists That Form Highly Stable Noncovalent Dimers
Authors: Chandramohan Kattamuri, David M. Luedeke, Kristof Nolan, Scott A. Rankin, Kenneth D. Greis, Aaron M. Zorn et al.
Journal of Molecular Biology
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