Mouse/Rat TLR7 Antibody Summary
Asn275-Phe444
Accession # P58681
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Mouse and Rat TLR7 by Western Blot. Western blot shows lysates of mouse thymus tissue and NR8383 rat alveolar macrophage cell line. PVDF membrane was probed with 1 µg/mL of Rat Anti-Mouse/Rat TLR7 Monoclonal Antibody (Catalog # MAB7156) followed by HRP-conjugated Anti-Rat IgG Secondary Antibody. A specific band was detected for TLR7 at approximately 130 to 140 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: TLR7
TLR7 (Toll-like receptor 7) is an approximately 130 kDa type I transmembrane glycoprotein and member of the Toll-like receptor family. Mouse TLR7 cDNA encodes 1050 amino acids (aa) including a 26 aa signal sequence and a 811 aa extracellular domain (ECD) with 28 leucine-rich repeats (LRR). Within the region used as an immunogen (LRR 10-16), mouse TLR7 shares 73% and 88% aa identity with human and rat TLR7, respectively. TLR7 mRNA is detected in brain, placenta, spleen, stomach, small intestine, lung, and in plasmacytoid dendritic cells, B cells and eosinophils. TLR7 participates in the innate immune response to microbial agents by recognizing viral and nonviral single stranded RNA.
Product Datasheets
Citations for Mouse/Rat TLR7 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 3
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Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells.
Authors: Khan A, Amu S, Saunders S, Hams E, Blackshields G, Leonard M, Weaver C, Sparwasser T, Sheils O, Fallon P
Eur J Immunol, 2015-04-14;45(6):1842-54.
Species: Mouse
Sample Types: Whole Cells
Applications: Western Blot -
The neonatal anti-viral response fails to control measles virus spread in neurons despite interferon-gamma expression and a Th1-like cytokine profile.
Authors: Ganesan P, Chandwani MN, Creisher PS et al.
Journal of Neuroimmunology
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TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury
Authors: Salik Hussain, Collin G Johnson, Joseph Sciurba, Xianglin Meng, Vandy P Stober, Caini Liu et al.
eLife
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