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Mouse SR-AI/MSR Antibody

Catalog #: AF1797
17 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
AF1797
AF1797-SP
Product Details
Citations (17)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse SR-AI/MSR Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse SR-A1/MSR in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse SR-AI/MSR
Trp79-Ser454
Accession # AAA39747
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Mouse SR-AI/MSR (Catalog # 1797-MS)
Blockade of Receptor-ligand Interaction
In a functional ELISA, 0.5-2 µg/mL of this antibody will block 50% of the binding of 100 ng/mL of biotinylated AGE‑BSA to immobilized Recombinant Mouse SR-AI/MSR1 (Catalog # 1797-MS) coated at 5 µg/mL (100 µL/well). At 20 µg/mL, this antibody will block >90% of the binding.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: SR-AI/MSR

The scavenger receptor (SR) family comprises a group of functionally defined membrane receptors that share the common ability to bind and internalize modified forms of Low Density Lipoproteins (mLDL) (1 - 3). Family members are classified alphabetically. The A class include four proteins: the three subtypes of SR-A (AI, AII, and AIII) that are generated by alternative splicing of the same gene, and a structurally similar protein named MARCO (4). All A class SRs are multidomain trimeric type II membrane proteins. SR-AI has an N-terminal cytoplasmic domain, a transmembrane domain, a spacer domain, an alpha -helical coiled coil, a collagen-like domain and a C-terminal cysteine-rich domain. SR-A is expressed by most tissue macrophages, dendritic cells and Kupffer cells. It is also highly expressed by microglia in neonatal as well as Alzheimer’ Disease brains. SR-AI binds a broad range of polyanionic ligands including modified proteins (e.g. Oxidized, acetylated or maleylated LDL, Advanced glycation end-product proteins), polyribonucleotides (polyguanosine and polyinosine), polysaccharides (dextran sulfate, fucoidan), phospholipids (phosphatidylserine), bacterial products (lipopolysaccharide and lipoteichoic acid) and selected chemical compounds (silica, crocidolite asbestos). The ligand-binding region has been localized to a positively charged region in the carboxyl end of the collagen-like domain. Based on its ligand binding characteristics, SR-AI is implicated in many physiological and pathophysiological functions. Studies using SR-A knockout mouse have also suggested roles of SR-A in atherogenesis, host defense and innate immunity, acquired immune responses, macrophage adhesion, and phagocytosis of apoptotic cells (1 - 3).

References
  1. Daugherty, A. et al. (2000) Curr. Opin. Cardiovasc. Pulm. Ren. Invest. Drugs 2:223.
  2. Platt, N. and S. Gordon (2001) J. Clin. Invest. 108:649.
  3. Platt, N. and S. Gordon (1998) Chem. Biol. 5:R193.
  4. Elomaa, O. et al. (1995) Cell 80:603.
Long Name
Macrophage Scavenger Receptor Types I and II
Entrez Gene IDs
4481 (Human); 20288 (Mouse); 25073 (Rat)
Alternate Names
CD204 antigen; CD204; Macrophage acetylated LDL receptor I and II; macrophage scavenger receptor 1; macrophage scavenger receptor type III; MSR1; phSR1; phSR2; SCARA1; SCARA1macrophage scavenger receptor types I and II; Scavenger receptor class A member 1; scavenger receptor class A, member 1; SR-A; SRAI; SR-AI

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Citations for Mouse SR-AI/MSR Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

17 Citations: Showing 1 - 10
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  1. Scavenger receptor SR-BI in macrophage lipid metabolism.
    Authors: Ji A, Meyer JM, Cai L et al.
    Atherosclerosis.
  2. Comparative Transcriptomic Analysis Identifies a Range of Immunologically Related Functional Elaborations of Lymph Node Associated Lymphatic and Blood Endothelial Cells
    Authors: Stella J. Berendam, Alexander F. Koeppel, Nicole R. Godfrey, Sherin J. Rouhani, Amber N. Woods, Anthony B. Rodriguez et al.
    Frontiers in Immunology
  3. The rebalancing of the immune system at the maternal-fetal interface ameliorates autism-like behavior in adult offspring
    Authors: Shen, C;Zhu, X;Chang, H;Li, C;Hou, M;Chen, L;Lu Chen, ;Zhou, Z;Ji, M;Xu, Z;
    Cell reports
    Species: Mouse
    Sample Types: Cell Lysates
  4. Advanced glycation end-products reduce lipopolysaccharide uptake by macrophages
    Authors: A Kitaura, T Nishinaka, S Hamasaki, OF Hatipoglu, H Wake, M Nishibori, S Mori, S Nakao, H Takahashi
    PLoS ONE, 2021-01-25;16(1):e0245957.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  5. LncRNA kcnq1ot1 promotes lipid accumulation and accelerates atherosclerosis via functioning as a ceRNA through the miR-452-3p/HDAC3/ABCA1 axis
    Authors: XH Yu, WY Deng, JJ Chen, XD Xu, XX Liu, L Chen, MW Shi, QX Liu, M Tao, K Ren
    Cell Death & Disease, 2020-12-09;11(12):1043.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  6. Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study
    Authors: F Hu, X Jiang, C Guo, Y Li, S Chen, W Zhang, Y Du, P Wang, X Zheng, X Fang, X Li, J Song, Y Xie, F Huang, J Xue, M Bai, Y Jia, X Liu, L Ren, X Zhang, J Guo, H Pan, Y Su, H Yi, H Ye, D Zuo, J Li, H Wu, Y Wang, R Li, L Liu, XY Wang, Z Li
    Nat Commun, 2020-04-20;11(1):1911.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  7. Effects of scavenger receptors-1 class A stimulation on macrophage morphology and highly modified advanced glycation end product-protein phagocytosis
    Authors: S Hamasaki, T Kobori, Y Yamazaki, A Kitaura, A Niwa, T Nishinaka, M Nishibori, S Mori, S Nakao, H Takahashi
    Sci Rep, 2018-04-12;8(1):5901.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  8. Exercise training enhances in vivo clearance of endotoxin and attenuates inflammatory responses by potentiating Kupffer cell phagocytosis
    Authors: S Komine, K Akiyama, E Warabi, S Oh, K Kuga, K Ishige, S Togashi, T Yanagawa, J Shoda
    Sci Rep, 2017-09-20;7(1):11977.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  9. Autophagy regulates phagocytosis by modulating the expression of scavenger receptors.
    Authors: Bonilla D, Bhattacharya A, Sha Y, Xu Y, Xiang Q, Kan A, Jagannath C, Komatsu M, Eissa N
    Immunity, 2013-09-12;39(3):537-47.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  10. The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis.
    Kidney Int, 2012-05-23;82(7):759-70.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  11. CD204 suppresses large heat shock protein-facilitated priming of tumor antigen gp100-specific T cells and chaperone vaccine activity against mouse melanoma.
    Authors: Qian J, Yi H, Guo C, Yu X, Zuo D, Chen X, Kane JM, Repasky EA, Subjeck JR, Wang XY
    J. Immunol., 2011-08-10;187(6):2905-14.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  12. Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells.
    Authors: Guimaraes EL, Empsen C, Geerts A, van Grunsven LA
    J. Hepatol., 2009-12-24;52(3):389-97.
    Species: Mouse
    Sample Types: Cell Lysates, Whole Cells
    Applications: ICC, Western Blot
  13. Pattern recognition scavenger receptor SRA/CD204 down-regulates Toll-like receptor 4 signaling-dependent CD8 T-cell activation.
    Authors: Yi H, Yu X, Gao P, Wang Y, Baek SH, Chen X, Kim HL, Subjeck JR, Wang XY
    Blood, 2009-04-06;113(23):5819-28.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  14. Cilostazol inhibits modified low-density lipoprotein uptake and foam cell formation in mouse peritoneal macrophages.
    Authors: Okutsu R, Yoshikawa T, Nagasawa M, Hirose Y, Takase H, Mitani K, Okada K, Miyakoda G, Yabuuchi Y
    Atherosclerosis, 2008-11-17;204(2):405-11.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  15. Biochanin A Mitigates Atherosclerosis by Inhibiting Lipid Accumulation and Inflammatory Response
    Authors: Xiao-Hua Yu, Jiao-Jiao Chen, Wen-Yi Deng, Xiao-Dan Xu, Qi-Xian Liu, Meng-Wen Shi et al.
    Oxidative Medicine and Cellular Longevity
  16. Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice
    Authors: Long Yang, Tingting Geng, Guang Yang, Jinzhu Ma, Leilei Wang, Harshada Ketkar et al.
    Communications Biology
  17. Feraheme (Ferumoxytol) Is Recognized by Proinflammatory and Anti-inflammatory Macrophages via Scavenger Receptor Type AI/II
    Authors: Guankui Wang, Natalie J. Serkova, Ernest V. Groman, Robert I. Scheinman, Dmitri Simberg
    Molecular Pharmaceutics

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