Mouse SR-AI/MSR APC-conjugated Antibody Summary
Trp79-Ser454
Accession # AAA39747
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of SR‑AI/MSR in RAW 264.7 Mouse Cell Line by Flow Cytometry. RAW 264.7 mouse monocyte/macrophage cell line was stained with Rat Anti-Mouse SR-AI/MSR APC-conjugated Monoclonal Antibody (Catalog # FAB1797A, filled histogram) or isotype control antibody (Catalog # IC013A, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: SR-AI/MSR
The scavenger receptor (SR) family comprises a group of functionally defined membrane receptors that share the common ability to bind and internalize modified forms of Low Density Lipoproteins (mLDL) (1‑3). Family members are classified alphabetically. The A class include four proteins: the three subtypes of SR-A (AI, AII, and AIII) that are generated by alternative splicing of the same gene, and a structurally similar protein named MARCO (4). All A class SRs are multidomain trimeric type II membrane proteins. SR-AI has an N-terminal cytoplasmic domain, a transmembrane domain, a spacer domain, an alpha -helical coiled coil, a collagen-like domain and a C-terminal cysteine-rich domain. SR-A is expressed by most tissue macrophages, dendritic cells and Kupffer cells. It is also highly expressed by microglia in neonatal as well as Alzheimer’ Disease brains. SR-AI binds a broad range of polyanionic ligands including modified proteins (e.g. Oxidized, acetylated or maleylated LDL, Advanced glycation end-product proteins), polyribonucleotides (polyguanosine and polyinosine), polysaccharides (dextran sulfate, fucoidan), phospholipids (phosphatidylserine), bacterial products (lipopolysaccharide and lipoteichoic acid) and selected chemical compounds (silica, crocidolite asbestos). The ligand-binding region has been localized to a positively charged region in the carboxyl end of the collagen-like domain. Based on its ligand binding characteristics, SR-AI is implicated in many physiological and pathophysiological functions. Studies using SR-A knockout mouse have also suggested roles of SR-A in atherogenesis, host defense and innate immunity, acquired immune responses, macrophage adhesion, and phagocytosis of apoptotic cells (1‑3).
- Daugherty, A. et al. (2000) Curr. Opin. Cardiovasc. Pulm. Ren. Invest. Drugs 2:223.
- Platt, N. and S. Gordon (2001) J. Clin. Invest. 108:649.
- Platt, N. and S. Gordon (1998) Chem. Biol. 5:R193.
- Elomaa, O. et al. (1995) Cell 80:603.
Product Datasheets
Citations for Mouse SR-AI/MSR APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 6
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The compound LG283 inhibits bleomycin-induced skin fibrosis via antagonizing TGF-beta signaling
Authors: A Utsunomiya, T Chino, H Kasamatsu, T Hasegawa, N Utsunomiya, VH Luong, T Matsushita, Y Sasaki, D Ogura, SI Niwa, N Oyama, M Hasegawa
Arthritis Research & Therapy, 2022-04-29;24(1):94.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Application of a three‑dimensional (3D) breast cancer model to study macrophage polarization
Authors: Agata Golabek, Mariusz Kaczmarek, Ewelina Dondajewska, Kosma Sakrajda, Andrzej Mackiewicz, Hanna Dams‑kozlowska
Experimental and Therapeutic Medicine
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Comparative Transcriptomic Analysis Identifies a Range of Immunologically Related Functional Elaborations of Lymph Node Associated Lymphatic and Blood Endothelial Cells
Authors: Stella J. Berendam, Alexander F. Koeppel, Nicole R. Godfrey, Sherin J. Rouhani, Amber N. Woods, Anthony B. Rodriguez et al.
Frontiers in Immunology
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Blockade of TGF-?/Smad signaling by the small compound HPH-15 ameliorates experimental skin fibrosis
Authors: VH Luong, T Chino, N Oyama, T Matsushita, Y Sasaki, D Ogura, SI Niwa, T Biswas, A Hamasaki, M Fujita, Y Okamoto, M Otsuka, H Ihn, M Hasegawa
Arthritis Res. Ther., 2018-03-15;20(1):46.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Scavenger Receptor A Mediates the Clearance and Immunological Screening of MDA-Modified Antigen by M2-Type Macrophages
Authors: Andreas Warnecke, Sonja Abele, Sravani Musunuri, Jonas Bergquist, Robert A. Harris
NeuroMolecular Medicine
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KIT oncogene inhibition drives intratumoral macrophage M2 polarization.
Authors: Cavnar, Michael, Zeng, Shan, Kim, Teresa S, Sorenson, Eric C, Ocuin, Lee M, Balachandran, Vinod P, Seifert, Adrian M, Greer, Jonathan, Popow, Rachel, Crawley, Megan H, Cohen, Noah A, Green, Benjamin, Rossi, Ferdinan, Besmer, Peter, Antonescu, Cristina, DeMatteo, Ronald P
J Exp Med, 2013-12-09;210(13):2873-86.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
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