Mouse TGF-beta RII PE-conjugated Antibody Summary
Ile24-Asp184
Accession # Q62312
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of TGF‑ beta RII in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Goat Anti-Mouse TGF-beta RII PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB532P, filled histogram) or isotype control antibody (Catalog # IC108P, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: TGF-beta RII
Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70-85 kDa), and Type III (250-350 kDa). The Type III receptor, a proteoglycan that exists in membrane-bound and soluble forms, binds TGF-beta 1, TGF-beta 2, and TGF-beta 3 but does not appear to be involved in signal transduction. The Type II receptor is a membrane-bound serine/threonine kinase that binds TGF-beta 1 and TGF-beta 3 with high affinity and TGF-beta 2 with a much lower affinity. The Type I receptor is also a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. Current evidence suggests that signal transduction requires the cytoplasmic domains of both the Type I and Type II receptors.
The recombinant soluble TGF-beta Type II receptor is capable of binding TGF-beta 1, TGF-beta 3, and TGF-beta 5 with sufficient affinity to act as an inhibitor of these isoforms at high concentrations. The soluble receptor also binds TGF-beta 2, but with an affinity at least two orders of magnitude lower. Binding of TGF-beta 1, TGF-beta 3, and TGF-beta 5 to the soluble TGF-beta Type II receptor can also be demonstrated by using the soluble receptor as a capture agent on ELISA plates and this observation has been used as the basis for the development of immunoassays for these isoforms of TGF-beta.
Product Datasheets
Citations for Mouse TGF-beta RII PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
17
Citations: Showing 1 - 10
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TGF-beta signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity
Authors: Sun X, Cui Y, Feng H et al.
J. Exp. Med.
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TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer
Authors: A Osman, B Yan, Y Li, KD Pavelko, J Quandt, A Saadalla, MP Singh, M Kazemian, F Gounari, K Khazaie
Nature Immunology, 2021-08-12;0(0):.
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Silencing miR-21-5p in sensory neurons reverses neuropathic allodynia via activation of TGF-beta –related pathway in macrophages
Authors: Lynda Zeboudj, George Sideris-Lampretsas, Rita Silva, Sabeha Al-Mudaris, Francesca Picco, Sarah Fox et al.
Journal of Clinical Investigation
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Histone deacetylases facilitate Th17-cell differentiation and pathogenicity in autoimmune uveitis via CDK6/ID2 axis
Authors: Zhang, C;Liu, X;Gu, C;Su, Y;Lv, J;Liu, Y;Gao, Y;Chen, H;Xu, N;Xiao, J;Xu, Z;Su, W;
Journal of advanced research
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Semmaphorin 3?A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells
Authors: Barnkob, MB;Michaels, YS;André, V;Macklin, PS;Gileadi, U;Valvo, S;Rei, M;Kulicke, C;Chen, JL;Jain, V;Woodcock, VK;Colin-York, H;Hadjinicolaou, AV;Kong, Y;Mayya, V;Mazet, JM;Mead, GJ;Bull, JA;Rijal, P;Pugh, CW;Townsend, AR;Gérard, A;Olsen, LR;Fritzsche, M;Fulga, TA;Dustin, ML;Jones, EY;Cerundolo, V;
Nature communications
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Kurarinone regulates Th17/Treg balance and ameliorates autoimmune uveitis via Rac1 inhibition
Authors: Gu, C;Liu, Y;Lv, J;Zhang, C;Huang, Z;Jiang, Q;Gao, Y;Tao, T;Su, Y;Chen, B;Jia, R;Liu, X;Su, W;
Journal of advanced research
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Progesterone attenuates Th17-cell pathogenicity in autoimmune uveitis via Id2/Pim1 axis
Authors: Liu, X;Gu, C;Lv, J;Jiang, Q;Ding, W;Huang, Z;Liu, Y;Su, Y;Zhang, C;Xu, Z;Wang, X;Su, W;
Journal of neuroinflammation
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Downregulation of Elovl5 promotes breast cancer metastasis through a lipid-droplet accumulation-mediated induction of TGF-beta receptors
Authors: TL Kieu, L Pierre, V Derangère, S Perrey, C Truntzer, A Jalil, S Causse, E Groetz, A Dumont, L Guyard, L Arnould, JP de Barros, L Apetoh, C Rébé, E Limagne, T Jourdan, L Demizieux, D Masson, C Thomas, F Ghiringhel, M Rialland
Cell Death & Disease, 2022-09-02;13(9):758.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
The induction and function of the anti-inflammatory fate of TH17 cells
Authors: H Xu, T Agalioti, J Zhao, B Steglich, R Wahib, MCA Vesely, P Bielecki, W Bailis, R Jackson, D Perez, J Izbicki, P Licona-Lim, V Kaartinen, J Geginat, E Esplugues, E Tolosa, S Huber, RA Flavell, N Gagliani
Nat Commun, 2020-07-03;11(1):3334.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Downregulation of CXCL12 in mesenchymal stromal cells by TGF? promotes breast cancer metastasis
Oncogene, 2016-09-26;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
TGF-? receptor maintains CD4 T helper cell identity during chronic viral infections
J Clin Invest, 2016-09-06;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Constitutive but not inducible attenuation of transforming growth factor beta signaling increases natural killer cell responses without directly affecting dendritic cells early after persistent viral infection.
Authors: Lewis G, Macal M, Hesser C, Zuniga E
J Virol, 2015-01-14;89(6):3343-55.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Transforming growth factor-beta signaling controls the formation and maintenance of gut-resident memory T cells by regulating migration and retention.
Authors: Zhang N, Bevan M
Immunity, 2013-09-26;39(4):687-96.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
PARP-1 regulates expression of TGF-beta receptors in T cells.
Authors: Zhang P, Nakatsukasa H, Tu E, Kasagi S, Cui K, Ishikawa M, Konkel J, Maruyama T, Wei G, Abbatiello B, Wang Z, Zhao K, Chen W
Blood, 2013-08-12;122(13):2224-32.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
TGF-beta signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation.
Authors: Zhang N, Bevan MJ
Nat. Immunol., 2012-05-27;13(7):667-73.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
TGF-beta limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function.
Authors: Rani R, Smulian AG, Greaves DR, Hogan SP, Herbert DR
Eur. J. Immunol., 2011-05-27;41(7):2000-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Intestinal CD11b+ B Cells Ameliorate Colitis by Secreting Immunoglobulin A
Authors: Ying Fu, Zhiming Wang, Baichao Yu, Yuli Lin, Enyu Huang, Ronghua Liu et al.
Frontiers in Immunology
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Followed the reference protocol, should incubate with TGFBRII-PE antibody in 37℃ 30mins, then stained other antibodies in 4℃.
