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Mouse Tryptase beta-1/MCP-7/Mcpt7 Antibody

Catalog #: MAB1937
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB1937
MAB1937-SP
Product Details
Citations (2)
FAQs
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse Tryptase beta-1/MCP-7/Mcpt7 Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse Tryptase beta ‑1/MCP‑7/Mcpt7 in direct ELISAs and Western blots. In direct ELISAs, 100% cross‑reactivity with recombinant human (rh) Tryptase alpha and rhTryptase beta ‑2 is observed and no cross-reactivity with recombinant mouse MCPT-1 is observed.
Source
Monoclonal Rat IgG2A Clone # 263019
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Tryptase beta ‑1/MCP‑7/Mcpt7
Ile29-Phe273
Accession # Q02844
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Mouse Tryptase  beta ‑1/MCP‑7/Mcpt7 (Catalog # 1937-SE)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Tryptase beta-1/MCP-7

Tryptase beta -1 is a serine protease with trypsin-like activity, which is sometimes also referred to as Mast Cell Protease 7 (MCP-7 or Mcpt7) (1). It is stored in the secretory granules of mouse mast cells (2). It exhibits anticoagulant activity due to its ability to degrade fibrinogen in the presence of the diverse array of protease inhibitors in plasma (3). The deduced amino acid (aa) sequence for mouse Tryptase beta -1 consists of a signal peptide (aa 1‑18), a pro region (aa 19‑28) and the mature chain (aa 29‑273).

References
  1. McNeil, H.P. et al. (1992) Proc. Natl. Acad. Sci. USA 89:11174.
  2. Matsumoto, R et al. (1995) J. Biol. Chem. 270:19524.
  3. Huang, C. et al. (1997) J. Biol. Chem. 272:31885.
Long Name
Mast Cell Protease 7
Entrez Gene IDs
100503895 (Mouse)
Alternate Names
Mast Cell Tryptase; Mcp7; MCP-7; Mcpt7; TPSB1; TRYB1; Tryptase beta1; Tryptase beta-1

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Citations for Mouse Tryptase beta-1/MCP-7/Mcpt7 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Mast cell-derived neurotrophin 4 mediates allergen-induced airway hyperinnervation in early life
    Mucosal Immunol, 2016-02-10;9(6):1466-1476.
    Species: Mouse
    Sample Types: Cell Lysates, Whole Cells
    Applications: IHC-P, Western Blot
  2. Acute oral ethanol exposure triggers asthma in cockroach allergen-sensitized mice.
    Authors: Bouchard J, Kim J, Beal D, Vaickus L, Craciun F, Remick D
    Am J Pathol, 2012-07-13;181(3):845-57.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: ELISA Development

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