Mouse Wnt-5b (AAH10775.1) VersaClone cDNA

Catalog #: RDC3725 Datasheet / COA / SDS

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RDC3725

Mouse Wnt-5b (AAH10775.1) VersaClone cDNA

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Mouse Wnt-5b (AAH10775.1) VersaClone cDNA Summary

Specifications

Source

N/A

Shipping Conditions

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Species

Mouse

Product Datasheets

Product Datasheet

COA

SDS

Background: Wnt-5b

Wnt-5b is a 49 kDa glycoprotein of the subgroup of Wnts that is implicated in the non-canonical Wnt/Ca²⁺ pathway. Wnt-5b is not axis-inducing in Xenopus embryos and only weakly transforms C57MG mammary epithelial cells. In adult mice, Wnt-5b is expressed in heart, liver, brain, lung, testes, kidney, and pancreas. Wnt-5b appears to promote adipogenesis and is upregulated in early adipogenesis. Also, Wnt-5b overexpression in 3T3-L1 cells partially inhibits canonical Wnt suppression of adipogenesis.

Human Wnt-5b polymorphisms have been associated with Type II diabetes. Although Wnt-5a and Wnt-5b share 83% amino acid identity, they show differential expression and regulation of cyclin D1 and p130 during endochondral bone development. Together, Wnt-5a and Wnt-5b appear to coordinate chondrocyte proliferation and differentiation. The expression of Wnt-5a and Wnt-5b are also implicated in limb development. Mature mouse Wnt-5b shows 94%, 98%, 90% and 88% amino acid identity with mature human, rat, chick and Xenopus Wnt-5b, respectively.

Long Name

Wingless-type MMTV Integration Site Family, Member 5b

Entrez Gene IDs

81029 (Human); 22419 (Mouse)

Alternate Names

MGC2648; protein Wnt-5b; wingless-type MMTV integration site family, member 5B; WNT-5B protein; Wnt5b; Wnt-5b