MRS 2768 tetrasodium salt
Chemical Name: Uridine-5'-tetraphosphate δ-phenyl ester tetrasodium salt
Purity: ≥98%
Biological Activity
MRS 2768 tetrasodium salt is a selective P2Y2 agonist (EC50 = 1.89 μM). Displays no affinity for human P2Y4 or P2Y6 receptors. In a mouse model of myocardial infarction, pre-treatment with MRS 2768 protects cardiocytes and heart tissue from ischemic damage, and reduces circulating levels of TNF-α.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Extracellular ATP exerts opposite effects on activated and regulatory CD4+ T cells via purinergic P2 receptor activation.
J. Immunol., 2012;189(3):1303-10. -
Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists.
Ko et al.
Bioorg.Med.Chem., 2008;16:6319
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Citations for MRS 2768 tetrasodium salt
The citations listed below are publications that use Tocris products. Selected citations for MRS 2768 tetrasodium salt include:
5 Citations: Showing 1 - 5
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Osmotic and hypoxic induction of osteopontin in retinal pigment epithelial cells: Involvement of purinergic receptor signaling.
Authors: Andreas Et al.
Mol Vis 2020;26:188-203
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Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium.
Authors: Shabir Et al.
PLoS Comput Biol 2013;305:F396
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Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.
Authors: Ilatovskaya Et al.
Am J Physiol Cell Physiol 2013;305:C1050
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Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries.
Authors: Alsaqati Et al.
Purinergic Signal 2013;10:241
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Extracellular ATP exerts opposite effects on activated and regulatory CD4+ T cells via purinergic P2 receptor activation.
Authors: Trabanelli Et al.
J Immunol 2012;189:1303
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