MRS 2957 triethylammonium salt
Chemical Name: P1-[5'(N4-Methoxycytidyl)]-P3-(5'-uridyl)-triphosphate tri(triethylammonium) salt
Purity: ≥99%
Biological Activity
MRS 2957 triethylammonium salt is a potent P2Y6 agonist (EC50 = 12 nM). Displays 14- and 66-fold selectivity against P2Y2 and P2Y4 receptors respectively.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Enhancement of glucose uptake in mouse skeletal muscle cells and adipocytes by P2Y6 receptor agonists.
Balasubramanian R, Robaye B, Boeynaems J, Jacobson K
PLoS ONE, 2014;9(12):e116203. -
Pyrimidine ribonucleotides with enhanced selectivity as P2Y6 receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate γ-ester modifications.
Maruoka et al.
J.Med.Chem., 2010;53:4488
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Citation for MRS 2957 triethylammonium salt
The citations listed below are publications that use Tocris products. Selected citations for MRS 2957 triethylammonium salt include:
1 Citation: Showing 1 - 1
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Enhancement of glucose uptake in mouse skeletal muscle cells and adipocytes by P2Y6 receptor agonists.
Authors: Balasubramanian Et al.
Nat Methods 2014;9:e116203
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