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MSA 2

Catalog #: 7353 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7353/10
7353/50
MSA 2 | CAS No. 129425-81-6 | STING Agonists
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Description: Non-nucleotide STING agonist; orally bioavailable

Chemical Name: 4-(5,6-Dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid

Purity: ≥98%

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Biological Activity

MSA 2 is a non-nucleotide STING agonist (EC50 values are 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively). Exhibits antitumor activity and stimulates interferon-β secretion in tumors. Induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models. Orally bioavailable.

Technical Data

M.Wt:
294.32
Formula:
C14H14O5S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
129425-81-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. An orally available non-nucleotide STING agonist with antitumor activity.
    Pan et al.
    Science, 2020;369:eaba6098

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