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MTK 458

Catalog #: 7980 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7980/10
7980/50
MTK 458 | CAS No. 2499962-58-0 | PINK1
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Description: PINK1 activator

Chemical Name: N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-6-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Purity: ≥98%

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Biological Activity

MTK 458 is a brain penetrant PTEN-induced kinase 1 (PINK1) activator. It binds to and stabilizes the active form of PINK1, increasing its activity and activating mitophagy downstream. It mediates clearance of pathogenic α-synuclein and normalizes pS65-Ubiquitin (pUb) in in vivo Parkinson's models. MTK458 is orally bioavailable.

Technical Data

M.Wt:
332.33
Formula:
C17H15F3N4
Solubility:
Soluble to 50 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2499962-58-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with kind permission of Mitokinin

Product Datasheets

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