N1,N11-Diethylnorspermine tetrahydrochloride
Chemical Name: N,N'-bis[3-(Ethylamino)propyl]-1,3-propanediamine tetrahydrochloride
Biological Activity
N1,N11-Diethylnorspermine tetrahydrochloride is a highly potent inducer of spermidine/spermine N1-acetyltransferase, able to increase enzyme activity 200-1000 fold.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Structural basis for differential induction of spermidine/spermine N1-acetyltransferase activity by novel spermine analogs.
Fogel-Petrovic et al.
Mol.Pharmacol., 1997;52:69 -
Antitumour activity of N1,N12-bis(ethyl)spermine homologs against human MALME-3 melanoma xenografts.
Bernacki et al.
Cancer Res., 1992;52:2424 -
Characterization of human spermidine spermine N1-acetyltransferase purified from cultured melanoma cells.
Libby et al.
Arch.Biochem.Biophys., 1991;284:238 -
Antitumour activity of N1,N12-bis(ethyl)-norspermine against human melanoma xenografts and possible biochemical correlates of drug action.
Porter et al.
Cancer Res., 1993;53:581
Product Datasheets
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Citation for N1,N11-Diethylnorspermine tetrahydrochloride
The citations listed below are publications that use Tocris products. Selected citations for N1,N11-Diethylnorspermine tetrahydrochloride include:
1 Citation: Showing 1 - 1
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Spermidine/spermine-N1-acetyltransferase ablation impacts tauopathy-induced polyamine stress response.
Authors: Sandusky-Beltran Et al.
Alzheimers Res Ther 2019;11:58
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