N⁶-Cyclohexyladenosine

Biological Activity

N⁶-Cyclohexyladenosine is a high affinity adenosine A₁ receptor agonist (K_d values are 0.7 and 6 nM for bovine and guinea pig brain membranes, respectively). Reduces light-induced circadian phase delays. Exhibits protective effect in lysolecithin-induced demyelination model. When administered prior to ischemia, improves functional recovery of heart in a mouse model of ischemia-reperfusion injury. Induces hypothermia following icv administration in mice.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Adenosine receptors in brain membranes: binding of N6-cyclohexyl[³H]adenosine and 1,3-diethyl-8-[³H]phenylxanthine.
   Bruns et al.
   Proc.Natl.Acad.Sci.U.S.A., 1980;77:5547
2. Adenosine A₁ receptors regulate the response of the mouse circadian clock to light.
   Sigworth and Rea et al.
   Brain Res., 2003;960:246
3. Adenosine A₁ receptor agonist, N⁶-cyclohexyladenosine, protects myelin and induces remyelination in an experimental model of rat optic chiasm demyelination; electrophysiological and histopathological studies.
   Asghari et al.
   J.Neurol.Sci., 2013;325:22
4. Adenosine A₁ receptor activation increases myocardial protein S-nitrosothiols and elicits protection from ischemia-reperfusion injury in male and female hearts.
   Shao et al.
   PLoS One, 2017;12:e0177315
5. Involvement of orexin neurons in fasting- and central adenosine-induced hypothermia.
   Futatsuki et al.
   Sci.Rep., 2018;8:2717

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