NAD 299 hydrochloride

Catalog #: 3282
1 Citation Datasheet / COA / SDS

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NAD 299 hydrochloride | CAS No. 184674-99-5 | 5-HT1A Receptor Antagonists

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Description: Selective, high affinity 5-HT1A antagonist

Chemical Name: (3R)-3-(Dicyclobutylamino)-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide hydrochloride

Purity: ≥98%

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Product Details

Citations (1)

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Biological Activity

NAD 299 hydrochloride is a selective, high affinity 5-HT_1A receptor antagonist (K_i = 0.6 nM in vitro). Enhances the action of selective 5-HT reuptake inhibitors and reverses citalopram-induced (Cat. No. 1427) inhibition of serotonergic cell firing.

Technical Data

M.Wt:

354.85

Formula:

C₁₈H₂₃FN₂O₂.HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

≥98%

Storage:

Desiccate at RT

CAS No:

184674-99-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold for research purposes under agreement from AstraZeneca

Background References

Differential regional antagonism of 8-OH-DPAT-induced decrease in serotonin synthesis by two 5-HT_1A receptor antagonists.
Larsson et al.
Eur.J.Pharmacol., 1998;346:209
The 5-HT_1A receptor antagonist robalzotan completely reverses citalopram-induced inhibition of serotonergic cell firing.
Arborelius et al.
Eur.J.Pharmacol., 1999;382:133

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Citation for NAD 299 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for NAD 299 hydrochloride include:

1 Citation: Showing 1 - 1

Protective effects of 5-HT1A receptor antagonist and 5-HT2A receptor agonist on the biochemical and histological features in a rat model of Alzheimer's disease.
Authors: Afshar Et al.
J.Chem.Neuroanat. 2019;96:140

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