NCL 00017509
Chemical Name: 3-[(6-Ethynyl-9H-purin-2-yl)amino]benzeneacetamide
Purity: ≥97%
Biological Activity
NCL 00017509 is a potent and reversible NIMA related kinase 2 (Nek2) inhibitor (IC50 = 56 nM). Induces increased mitotic abnormalities and mitotic delay. Cell permeable and active in vivo. In mice bearing pancreatic tumors, NCL 00017509 decreases PD-L1 expression and induces an anticancer immune response.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles.
Lebraud et al.
Org.Biomol.Chem., 2014;12:141
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Citation for NCL 00017509
The citations listed below are publications that use Tocris products. Selected citations for NCL 00017509 include:
1 Citation: Showing 1 - 1
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NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1.
Authors: Zhang Et al.
Nat Commun. 2021;12:4536
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