NCX 4040
Chemical Name: 2-(Acetyloxy)benzoic acid 4-[(nitrooxy)methyl]phenyl ester
Purity: ≥98%
Biological Activity
NCX 4040 is a NO-donating aspirin; anti-inflammatory. Blocks inflammatory mediator production in isolated human monocytes (IC50 values are 0.07, 0.13, 0.15 and 0.18 μM for IL-1β, PGE2, IL-10 and TNF-α respectively). Decreases COX-2 expression (IC50 = 0.13 μM); disrupts proteasome-mediated degradation of iκB-α. Antiproliferative in HCT116 colon cancer cells; sensitizes drug-resistant ovarian tumor cells to cisplatin (Cat. No. 2251).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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NCX 4040, a nitric oxide-donating aspirin, exerts anti-inflammatory effects through inhibition of I kappa B-alpha degradation in human monocytes.
Ricciotti et al.
J.Immunol., 2010;184:2140 -
Growth inhibition of human colon cancer cell line HCT116 by bis[2-(acylamino)phenyl] disulfide and its action mechanism.
Yamakawa et al.
Biol.Pharm.Bull., 2008;31:916 -
NCX-4040, a nitric oxide-releasing aspirin, sensitizes drug-resistant human ovarian xenograft tumors to cisp. by depletion of cellular thiols.
Bratasz et al.
J.Transl.Med., 2008;6:9 -
Immunomodulatory activity of synthetic triterpenoids: inhibition of lymphocyte proliferation, cell-mediated cytotoxicity, and cytokine gene expression through suppression of NF-κB.
Gao et al.
Immunopharmacol.Immunotoxicol., 2008;30:581
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