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NE 100 hydrochloride

Catalog #: 3133
8 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3133/10
3133/50
NE 100 hydrochloride | CAS No. 149409-57-4 | Sigma1 Receptor Antagonists
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Description: Selective σ1 antagonist

Chemical Name: 4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine hydrochloride

Purity: ≥98%

Product Details
Citations (8)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

NE 100 hydrochloride is a potent and selective σ1 receptor antagonist (Ki = 0.86 nM) that displays > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1, D2, 5-HT1A, 5-HT2 and PCP receptors. Exhibits reversible binding (Kd = 1.2 nM) and displays antipsychotic activity in vivo. Orally active.

Technical Data

M.Wt:
391.97
Formula:
C23H33NO2.HCl
Solubility:
Soluble to 5 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
149409-57-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. NE-100, a novel potent σ ligand, preferentially binds to σ1 binding sites in guinea pig brain.
    Chaki et al.
    Eur.J.Pharmacol., 1994;251:R1
  2. NE-100, a novel sigma receptor ligand: in vivo tests.
    Okuyama et al.
    Pharmacol.Letts., 1993;53:PL285
  3. Characteristics of binding of [3H]NE-100, a novel sigma-receptor ligand, to guinea-pig brain membranes.
    Tanaka et al.
    Naunyn Schmied.Arch.Pharmacol., 1995;351:244

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Citations for NE 100 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for NE 100 hydrochloride include:

8 Citations: Showing 1 - 8

  1. Development of a novel σ1 receptor biosensor based on its heterodimerization with binding immunoglobulin protein in living cells.
    Authors: Morat? Et al.
    ACS Chem.Neurosci.  2023;
  2. Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome.
    Authors: Song Et al.
    Nat.Card.Res.  2022;1:142
  3. Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy.
    Authors: Atzmon Et al.
    Front Mol Neurosci  2018;11:336
  4. Amyloid toxicity is enhanced after pharmacological or genetic invalidation of the σ1 receptor.
    Authors: Maurice
    Behav Brain Res  2017;339:1
  5. The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.
    Authors: Rodríguez-Muñoz Et al.
    Br J Pharmacol  2015;6:35458
  6. The effects of σ (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice.
    Authors: Malik Et al.
    Int J Neuropsychopharmacol  2015;172:2519
  7. The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
    Authors: Sánchez-Blázquez Et al.
    Eur J Immunol  2014;17:1943
  8. A 96-well filtration method for radioligand binding analysis of σ receptor ligands.
    Authors: Fishback Et al.
    J Pharm Biomed Anal  2012;71:157

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