Ned K

Catalog #: 5976 Datasheet / COA / SDS

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Ned K | CAS No. 2250019-90-8 | Calcium Signaling Agents

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Description: Prevents Ca2+ oscillations in cardiomyocytes during ischemia/reperfusion; NAADP signaling inhibitor

Chemical Name: (1R,3S)-1-[3-[[4-(2-Cyanophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

Purity: ≥98%

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Biological Activity

Ned K is a NAADP inhibitor. Prevents Ca²⁺ oscillations in rat cardiomyocytes in vitro during simulated ischemia and reperfusion, but exhibits no significant effect on Ca²⁺ sparks. Significantly reduces infarct size in rat cardiac ischemia/reperfusion model in vivo.

Technical Data

M.Wt:

521.61

Formula:

C₃₁H₃₁N₅O₃

Solubility:

Soluble to 50 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

2250019-90-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore.
Davidson et al.
Cardiovasc.Res., 2015;108:357

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