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NF 546

Catalog #: 3892
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3892/10
NF 546 | CAS No. 1006028-37-0 | P2Y Receptor Agonists
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Description: Selective P2Y11 agonist

Chemical Name: 4,4'-(Carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)carbonylimino))-bis(1,3-xylene-alpha,alpha'-diphosphonic acid tetrasodium salt

Purity: ≥95%

Product Details
Citations (5)
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Biological Activity

NF 546 is a P2Y11 agonist (pEC50 = 6.27). Exhibits selectivity for P2Y11 over a range of P2Y and P2X receptors. Also inhibits DNA-binding activity of HMGA2 (IC50 = 5.49 μM).

Technical Data

M.Wt:
1180.74
Formula:
C47H44N6Na4O17P4
Solubility:
Soluble to 10 mM in water with gentle warming
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
1006028-37-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for NF 546

The citations listed below are publications that use Tocris products. Selected citations for NF 546 include:

5 Citations: Showing 1 - 5

  1. Differential Regulation of ATP- and UTP-Evoked Prostaglandin E2 and IL-6 Production from Human Airway Epithelial Cells.
    Authors: Timothy S Et al.
    J Immunol  2021;207:1275-1287
  2. Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays.
    Authors: Su Et al.
    Sci Rep  2020;10:18850
  3. A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia.
    Authors: Johannes W Et al.
    Elife  2019;8
  4. Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells.
    Authors: Barragán-Iglesias Et al.
    Mol Pain  2014;10:29
  5. The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells.
    Authors: Gao Et al.
    Sci Adv  2013;9:31

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