NHI 2
Chemical Name: Methyl 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate
Purity: ≥98%
Biological Activity
NHI 2 is an LDHA inhibitor; reduces lactate production in HeLa cells. Inhibits cell growth of LPC006 and PANC-1 cells in vitro. Enhances the antiproliferative effects of Gemcitabine (Cat. No. 3259) on LPC006 and PANC-1 cells. Also inhibits ferroptosis.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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APD-containing cyclolipodepsipeptides target mitochondrial function in hypoxic cancer cells.
Jacobsen et al.
Cell Chem.Biol., 2018;25:1337 -
Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor.
Calvaresi et al.
Chembiochem, 2013;14:2263 -
Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds.
Granchi et al.
Org.Biomol.Chem., 2013;11:6588 -
Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcit. against pancreatic cancer cells in hypoxia.
Maftouh et al.
Br.J.Cancer, 2014;110:172
Product Datasheets
Citation for NHI 2
The citations listed below are publications that use Tocris products. Selected citations for NHI 2 include:
1 Citation: Showing 1 - 1
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Akt-mediated Ephexin1-Ras interaction promotes oncogenic Ras signaling and colorectal and lung cancer cell proliferation.
Authors: Jung-Hee Et al.
Cell Death Dis 2021;12:1013
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