NI 57
Chemical Name: 4-Cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-methoxybenzene-1-sulfonamide
Purity: ≥98%
Biological Activity
NI 57 is a potent and selective BRPF bromodomain inhibitor (Kd values are 31, 108 and 408 nM, for BRPF1B, 2 and 3, respectively, which exhibits >32-fold selectivity for BRPFs over BRD9 and other non-Class IV bromodomains. NI 57 inhibits RANKL-induced differentiation of primary murine bone marrow cells and human primary monocytes into osteoclasts.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of NI 57 is reviewed on the chemical probes website.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
-
Design of a chemical probe for the bromodomain and plant homeodomain finger-containing (BRPF) family of proteins.
Igoe et al.
J.Med.Chem., 2017;60:6998 -
Selective targeting of bromodomains of the bromodomain-PHD fingers family impairs osteoclast differentiation.
Meier et al.
ACS Chem.Biol., 2017;12:2619
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