Nocistatin (bovine)

Name: Nocistatin (bovine)
Brand: Tocris Bioscience
SKU: 1118

Catalog #: 1118 Datasheet / COA / SDS

Discontinued Product

1118 has been discontinued.

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Description: Opposes action of nociceptin

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Biological Activity

An endogenous peptide derived from the same precursor as nociceptin, which is able to block nociceptin-induced allodynia and hyperalgesia and may play an opposing role in pain transmission. Shown to reverse nociceptin inhibition of glutamate release from rat brain slices; also modulates 5-HT transmission in the mouse neocortex via mechanisms separate from nociceptin/orphanin FQ.

Technical Data

M.Wt:

1927.07

Formula:

C₈₂H₁₃₅N₂₁O₃₂

Sequence:

TEPGLEEVGEIEQKQLQ

Solubility:

Soluble to 2 mg/ml in PBS

Storage:

Desiccate at -20°C

CAS No:

208253-85-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Nocistatin inhibits 5-hydroxytryptamine release in the mouse neocortex via presynaptic G_i/o protein linked pathways.
Fantin et al.
Br.J.Pharmacol., 2007;152:549
Nocistatin, a peptide that blocks nociceptin action in pain transmission.
Okuda-Ashitaka et al.
Nature, 1998;392:286
Nocistatin reverses nociceptin inhibition of glutamate release from rat brain slices.
Nicol et al.
Eur.J.Pharmacol., 1998;356:R1
Effect of nocistatin and its interaction with nociceptin/orphanin FQ on the rat formalin test.
Yamamoto et al.
Neurosci.Lett., 1999;262:179

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