Non-Human Primate Fas Ligand Cartridge New

Non-Human Primate Fas Ligand Cartridge Summary

*The Sample Volume represented is based on the amount of sample incorporated into the reaction after taking into account the assay’s minimum required dilution for a given matrix. Serial dilution may be necessary to achieve some of the final sample volumes represented.

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Preparation and Storage

Background: Fas Ligand/TNFSF6

Fas Ligand (FasL), also known as CD178, CD95L, or TNFSF6, is a transmembrane protein homotrimer that binds to Fas/CD95 and triggers apoptosis in the Fas-expressing cell. Fas Ligand also binds the soluble decoy receptor DcR3. It is expressed on activated Th1 cells, CD8+ cytotoxic T cells, and NK cells. A soluble form can be released which remains trimeric and retains the ability to bind Fas. Fas Ligand-induced apoptosis plays a central role in the development of immune tolerance and the maintance of immune privileged sites. Tumor cells can evade immune surveillance by upregulating Fas Ligand to kill tumor infiltrating lymphocytes. In gld mice, a Fas Ligand point mutation is the cause of severe lymphoproliferation and systemic autoimmunity.

Related Research Areas

• Epithelial Cell Markers and Intracellular Molecules
• gamma delta T Cells
• Isolation, Culture, and Identification of Natural Killer Cells
• Natural Killer T (NKT) Cells
• Regulation of Apoptosis by TNF Superfamily Members
• Search Cytokine and Growth Factor Products
• Surface Ectodermal Cells
• TNF Superfamily
• TNF Superfamily Ligands