Noscapine hydrochloride

Biological Activity

Noscapine hydrochloride is an opioid alkaloid with several actions. Binds to tubulin, arrests cells in mitosis and induces apoptosis. Antagonist at bradykinin receptors (pA₂ = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues. Modulates IKK activation, suppressing the NF-κB signaling pathway. Blocks proliferation of human leukemia and multiple myeloma cells. Exhibits anti-inflammatory activity.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Antifibrotic effects of noscapine through activation of prostaglandin E2 receptors and protein kinase A.
   Kach J, Sandbo N, La J, Denner D, Reed E, Akimova O, Koltsova S, Orlov S, Dulin N
   J Biol Chem, 2014;289(11):7505-13.
2. Effect of noscapine, the antitussive opioid alkaloid, on bradykinin-induced smooth muscle contraction in the isolated ileum of the guinea-pig.
   Mahmoudian and Mojaverian
   Acta Physiol.Hung., 2001;88:231
3. Noscapine alters microtubule dynamics in living cells and inhibits the progression of melanoma.
   Landen et al.
   Cancer Res., 2002;62:4109
4. [³H]Noscapine binding sites in brain: relationship to indoleamines and the phosphoinositide and adenylyl cyclase messenger systems.
   Mourey et al.
   Mol.Pharmacol., 1992;42:619
5. Noscapine, a benzylisoquinoline alkaloid, sensitizes leukemic cells to chemotherapeutic agents and cytokines by modulating the NF-κB signaling pathway.
   Sung et al.
   Cancer Res., 2010;70:3259

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