[Nphe¹]Nociceptin(1-13)NH₂

Name: [Nphe 1 ]Nociceptin(1-13)NH 2
Brand: Tocris Bioscience
SKU: 1308

Catalog #: 1308
3 Citations Datasheet / COA / SDS

Discontinued Product

1308 has been discontinued.

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Description: Selective, competitive nociceptin antagonist

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Product Details

Citations (3)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

[Nphe¹]Nociceptin(1-13)NH₂ is a selective and competitive nociceptin receptor antagonist, devoid of any agonist activity. Binds selectively to recombinant nociceptin receptors (pK_i = 8.4), and competitively antagonizes the actions of nociceptin in vitro and in vivo.

Technical Data

M.Wt:

1381.6

Formula:

C₆₁H₁₀₀N₂₂O₁₅

Sequence:

GGGFTGARKSARK

(Modifications: Gly-1 = N-Bn-Gly, Lys-13 = C-terminal amide)

Solubility:

Soluble to 1 mg/ml in 10% acetonitrile

Storage:

Desiccate at -20°C

CAS No:

267234-08-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Antagonistic effects of [Nphe¹]nociceptin(1-13)NH₂ on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor.
Hashimoto et al.
Neurosci.Lett., 2000;278:109
Characterization of [Nphe¹]nociceptin(1-13)NH₂, a new selective nociceptin receptor antagonist.
Calo et al.
Br.J.Pharmacol., 2000;129:1183
[Nphe¹]nociceptin-(1-13)NH₂ selectively antagonizes nociceptin effects in the rabbit isolated ileum.
Pheng et al.
Eur.J.Pharmacol., 2000;397:383

Product Datasheets

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Citations for [Nphe¹]Nociceptin(1-13)NH₂

The citations listed below are publications that use Tocris products. Selected citations for [Nphe¹]Nociceptin(1-13)NH₂ include:

3 Citations: Showing 1 - 3

ORL₁ activation mediates a novel ORL₁ receptor agonist SCH221510 analgesia in neuropathic pain in rats.
Authors: Wu & Liu
J Mol Neurosci 2018;66:10
Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.
Authors: Schmid Et al.
Cell 2017;171:1165
Nociceptin/orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naive and ethanol-dependent rats.
Authors: Kallupi Et al.
Neuropsychopharmacology 2014;39:1081

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[Nphe1]Nociceptin(1-13)NH2