Home / Ca2+-Activated Potassium Channel Activators / NS 11021

NS 11021

Catalog #: 4788
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4788/10
4788/50
NS 11021 | CAS No. 956014-19-0 | Ca2+-Activated Potassium Channel Activators
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Description: KCa1.1 (BK) channel activator

Chemical Name: N'-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

NS 11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Exhibits no modulatory effect on a variety of K+ (KV), Na+ and Ca2+ currents at concentrations <10 μM. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BKCa in open and closed conformations; thought to bind the α subunit.

Technical Data

M.Wt:
511.24
Formula:
C16H9BrF6N6S
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
956014-19-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for NS 11021

The citations listed below are publications that use Tocris products. Selected citations for NS 11021 include:

2 Citations: Showing 1 - 2

  1. FMRP Sustains Presynaptic Function via Control of Activity-Dependent Bulk Endocytosis.
    Authors: Peter C Et al.
    J Neurosci  2022;42:1618-1628
  2. Molecular basis of ancestral vertebrate electroreception.
    Authors: Bellono
    Nature  2017;543:391

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