NS 1643
Chemical Name: N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea
Purity: ≥98%
Biological Activity
NS 1643 is a human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM). Exhibits different molecular mechanisms of action at KV11.1 (hERG1) and KV11.2 (hERG2) channels. Displays antiarrhythmic activity in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Activation of human ether-a-go-go related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643).
Hansen et al.
Mol.Pharmacol., 2006;69:266 -
Mechanism of action of a novel human ether-a-go-ao related gene channel activator.
Casis et al.
Mol.Pharmacol., 2006;69:658 -
Activation of ERG2 potassium channel by the diphenylurea NS1643.
Elmedyb et al.
Neuropharmacology, 2007;53:283
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Citation for NS 1643
The citations listed below are publications that use Tocris products. Selected citations for NS 1643 include:
1 Citation: Showing 1 - 1
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Kinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel.
Authors: Perissinotti Et al.
Biophys J 2015;108:1414
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