Home / Other Chloride Channel Blockers / NS 3728

NS 3728

Catalog #: 6973 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6973/10
6973/50
NS 3728 | CAS No. 265646-85-3 | Other Chloride Channel Blockers
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Description: VRAC blocker
Alternative Names: Endovion

Chemical Name: N-[3,5-bis(Trifluoromethyl)phenyl]-N'-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]urea

Purity: ≥98%

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Biological Activity

NS 3728 is a volume-regulated anion channel (VRAC) blocker (IC50 = 460 nM). Blocks red blood cell chloride conductance (IC50 = 0.6 μM). NS 3728 also inhibits Ca2+-activated Cl- current (CaCC) by anoctamin (ANO) in an apparently voltage-dependent manner (IC50 against ANO1 = 2.1 and 0.7 μM at -95 and +50 mV, respectively).

Technical Data

M.Wt:
495.18
Formula:
C16H9BrF6N6O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
265646-85-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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