NS 5806
Chemical Name: N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]urea
Purity: ≥99%
Biological Activity
NS 5806 is a KV4.3 channel activator; mediates the transient outward K+ current (Ito). Increases IKv4.3 peak current amplitude in CHO-K1 cells expressing KV4.3 and KChIP2 (EC50 = 5.3 μM). Inhibits KV1.4-mediated currents independently of KChIP2. Also slows the decay of KV4.2 and KV4.3 currents in the presence of KChIP2.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome.
Calloe et al.
Cardiovasc.Res., 2009;81:686 -
Differential effects of the transient outward K+ current activator NS5806 in the canine left ventricle.
Calloe et al.
J.Mol.Cell.Cardiol., 2010;48:191 -
Effect of the Ito activator NS5806 on cloned Kv4 channels depends on the accessory protein KChIP2.
Lundby et al.
Br.J.Pharmacol., 2010;160:2028
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Citation for NS 5806
The citations listed below are publications that use Tocris products. Selected citations for NS 5806 include:
1 Citation: Showing 1 - 1
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Modulation of the voltage-gated potassium channel (Kv4.3) and the auxiliary protein (KChIP3) interactions by the current activator NS5806.
Authors: Gonzalez Et al.
J Biol Chem 2014;289:32201
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