NS 9283
Chemical Name: 3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile
Purity: ≥99%
Biological Activity
NS 9283 is a positive allosteric modulator of α4β2 receptor; increases the potency of Ach-evoked currents ~60 fold without affecting the maximum efficacy (HEK293-hα4β2 cells). Reduces the rate of recovery from desensitization and slows the rate of deactivation. Displays a synergistic effect on the Emax when given with NS206 at 3α:2β receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Unravelling the mechanism of action of NS9283, a positive allosteric modulator of (α4)3(β2)2 nicotinic ACh receptors.
Grupe et al.
Br.J.Pharmacol., 2013;168:2000 -
Discriminative-stimulus effects of NS9283, a nicotinic α4β2* positive allosteric modulator, in nicotine-discriminating rats.
Mohler et al.
Psychopharmacology (Berl)., 2014;231:67 -
Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptor
Olsen et al.
J.Biol.Chem., 2013;288:35997
Product Datasheets
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Citation for NS 9283
The citations listed below are publications that use Tocris products. Selected citations for NS 9283 include:
1 Citation: Showing 1 - 1
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Unraveling amino acid residues critical for allosteric potentiation of (α4)3(β2)2-type nicotinic acetylcholine receptor responses.
Authors: Wang Et al.
J.Med.Chem. 2017;292:9988
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