NSC 109555 ditosylate

Catalog #: 3034
3 Citations Datasheet / COA / SDS

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NSC 109555 ditosylate | CAS No. 66748-43-4 | Checkpoint Kinase Inhibitors

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Description: Selective Chk2 inhibitor

Alternative Names: DDUG

Chemical Name: 2,2'-[Carbonylbis(imino-4,1-phenyleneethylidyne]bishydrazinecarboximidamide) bis(4-methylbenzenesulfonate)

Purity: ≥98%

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Product Details

Citations (3)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

NSC 109555 ditosylate is a selective, reversible, ATP-competitive Chk2 inhibitor (IC₅₀ = 0.2 μM) that displays no effect on a range of other kinases including Chk1 (IC₅₀ > 10 μM). Inhibits histone H1 phosphorylation (IC₅₀ = 0.24 μM) and attenuates mitochondrial ATP synthesis. Exhibits antiproliferative activity in a number of leukemias in vivo.

Technical Data

M.Wt:

752.86

Formula:

C₁₉H₂₄N₁₀O.2C₇H₈O₃S

Solubility:

Soluble to 10 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

66748-43-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Actions of bis(guanylhydrazones) on isolated rat liver mitochondria.
Byczkowski et al.
Biochem.Pharmacol., 1981;30:2851
Potentiation of the antimitochondrial and antiproliferative effects of bis(guanylhydrazones) by phenethylbiguanide.
Byczkowski et al.
Cancer Res., 1982;42:3592
Identification of a bis-guanylhydrazone [4,4'-diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase.
Jobson et al.
Mol.Pharmacol., 2007;72:876

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Citations for NSC 109555 ditosylate

The citations listed below are publications that use Tocris products. Selected citations for NSC 109555 ditosylate include:

3 Citations: Showing 1 - 3

Inhibition of checkpoint kinase 2 (CHK2) enhances sensitivity of pancreatic adenocarcinoma cells to gemcit.
Authors: Duong Et al.
J Cell Mol Med 2013;17:1261
The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway.
Authors: Fard Et al.
Cell Cycle 2013;13:408
Parvovirus B19 infection of human primary erythroid progenitor cells triggers ATR-Chk1 signaling, which promotes B19 virus replication.
Authors: Luo Et al.
J Virol 2011;85:8046

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