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NSC 33994

Catalog #: 4338
1 Citation Datasheet / COA / SDS

Discontinued Product

4338 has been discontinued.
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NSC 33994 | CAS No. 82058-16-0 | JAK Kinase Inhibitors
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Description: JAK2 inhibitor

Chemical Name: E-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]phenol

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

NSC 33994 is a selective inhibitor of JAK2 (IC50 = 60 nM). Displays no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.

Technical Data

M.Wt:
438.65
Formula:
C28H42N2O2
Solubility:
Soluble to 5 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
82058-16-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening.
    Kiss et al.
    Bioorg.Med.Chem.Lett., 2009;19:3598

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Citation for NSC 33994

The citations listed below are publications that use Tocris products. Selected citations for NSC 33994 include:

1 Citation: Showing 1 - 1

  1. Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis.
    Authors: Zhu Et al.
    Oncogene  2016;35:5388

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