NSC 632839 hydrochloride
Discontinued Product
Chemical Name: 3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride
Purity: ≥99%
Biological Activity
NSC 632839 hydrochloride is an inhibitor of ubiquitin isopeptidase activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 values are 15.65 and 16.23 μM in E1A and E1A/C9CN cells respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis.
Aleo et al.
Cancer Res., 2006;66:9235
Product Datasheets
Citations for NSC 632839 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for NSC 632839 hydrochloride include:
2 Citations: Showing 1 - 2
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The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity.
Authors: Ryals Et al.
Front Cell Neurosci 2018;12:445
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CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection.
Authors: Zeng Et al.
Nature 2016;7:11364
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