OD1

Biological Activity

OD1 is a potent rat Na_v1.7, human Na_v1.4 and rat Na_v1.6 channel activator (EC₅₀ values are 7, 10 and 47 nM, respectively). Exhibits minimal activation at mammalian Na_v1.2, Na_v1.3 and Na_v1.5 (EC₅₀ values >3 μM). Inhibits fast inactivation on all channels. Increases peak currents at all voltages and stimulates a persistent Na⁺ current at hNa_v1.7 channel. Increases hyperpolarization at Na_v1.4 and Na_v1.6 channels. Induces spontaneous pain in vivo.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. OD1, the first toxin isolated from the venom of the scorpion Odonthobuthus doriae active on voltage-gated Na⁺ channels.
   Jalali et al.
   FEBS Lett., 2005;579:4181
2. Potent modulation of the voltage-gated sodium channel Na_v1.7 by OD1, a toxin from the scorpion Odonthobuthus doriae.
   Maertens et al.
   Mol.Pharmacol., 2006;70:405
3. Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1.
   Durek et al.
   ACS Chem.Biol., 2013;8:1215

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