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Ogerin

Catalog #: 5722 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5722/10
5722/50
Ogerin | CAS No. 1309198-71-7 | Orphan 7-TM Receptor Agonists
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Description: Selective positive allosteric modulator at GPR68

Chemical Name: 2-[4-Amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]benzenemethanol

Purity: ≥98%

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Biological Activity

Ogerin is a selective positive allosteric modulator (PAM) of GPR68 (pEC50 = 6.83), which exhibits selectivity for GPR68 over 58 other GPCRs. Ogerin attenuates contextual-based fear memory in mice.

External Portal Information

Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of Ogerin is reviewed on chemicalprobes.org and the SGC website.

Technical Data

M.Wt:
307.35
Formula:
C17H17N5O
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1309198-71-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.
    Huang et al.
    Nature, 2015;527:477

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