Home / Poly(ADP-ribose) Polymerase Inhibitors / Olaparib

Olaparib

Catalog #: 7579
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7579/10
7579/50
Olaparib | CAS No. 763113-22-0 | Poly(ADP-ribose) Polymerase Inhibitors
1 Image
Description: Potent PARP inhibitor

Chemical Name: 4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Product Datasheets Calculators

Biological Activity

Olaparib is a potent PARP2 and PARP1 inhibitor (IC50 values are 1 and 5 nM, respectively). Olaparib abolishes PARP-1 activity at a concentration of 30-100 nM in SW620 cell lysates. BRCA1-deficient cell lines are hypersensitive to PARP inhibition by Olaparib in comparison with BRCA1- and BRCA2-proficient cells. Olaparib potentiates the antitumor activity of the methylating chemotherapeutic agent Temozolomide (Cat. No. 2706) in xenograft mouse model. Olaparib is orally bioavailable in rats.

Technical Data

M.Wt:
434.47
Formula:
C24H23FN4O3
Solubility:
Soluble to 5 mM in ethanol with gentle warming and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
763113-22-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for Olaparib

The citations listed below are publications that use Tocris products. Selected citations for Olaparib include:

1 Citation: Showing 1 - 1

  1. Sequential Targeting of PLK1 and PARP1 Reverses the Resistance to PARP Inhibitors and Enhances Platin-Based Chemotherapy in BRCA-Deficient High-Grade Serous Ovarian Cancer with KRAS Amplification.
    Authors: Monika Et al.
    Int J Mol Sci  2022;23

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Olaparib

There are currently no reviews for this product. Be the first to review Olaparib and earn rewards!

Have you used Olaparib?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.