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Olopatadine hydrochloride

Catalog #: 4241 Datasheet / COA / SDS
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4241/10
4241/50
Olopatadine hydrochloride | CAS No. 140462-76-6 | Histamine H1 Receptor Antagonists
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Description: H1 antagonist; ocular antiallergic agent

Chemical Name: (Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydro-dibenz[b,e]oxepin-2-acetic acid hydrochloride

Purity: ≥99%

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Biological Activity

Olopatadine hydrochloride is a histamine H1 receptor antagonist (Ki = 31.6 nM). Inhibits the release of histamine, prostaglandin D2 and tryptase in a concentration-dependent manner. Mast cell stabilizer; inhibits mast cell mediator release. Also suppresses inflammation by inhibition of cytokine production.

Technical Data

M.Wt:
373.87
Formula:
C21H23NO3.HCl
Solubility:
Soluble to 75 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
140462-76-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria.
    Fujisawa D, Kashiwakura J, Kita H, Kikukawa Y, Fujitani Y, Sasaki-Sakamoto T, Kuroda K, Nunomura S, Hayama K, Terui T, Ra C, Okayama Y
    J Allergy Clin Immunol, 2014;134(3):622-633.e9.
  2. Olopatidine ameliorates rat experimental cutaneous inflammation by improving skin barrier function.
    Tamura et al.
    Pharmacology, 2007;81:118

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