Olvanil
Chemical Name: N-Vanillyloleoylamide
Purity: ≥98%
Biological Activity
Olvanil is a potent vanilloid receptor agonist (pEC50 values are 8.1 and 7.7 at rat and human VR1 receptors respectively). Also blocks anandamide uptake (IC50 = 9 μM) and may bind to CB1 cannabinoid receptors. Antinociceptive following systemic administration.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Diabetes Stimulates Osteoclastogenesis by Acidosis-Induced Activation of Transient Receptor Potential Cation Channels
Sci Rep, 2016;6(0):30639. -
Interactions between synthetic vanilloids and the endogenous cannabinoid system.
Di Marzo et al.
FEBS Lett., 1998;436:449 -
NE-19550 and NE-21610, antinociceptive capsaicin analogues: studies on nociceptive fibres of the neonatal rat tail in vitro.
Dray et al.
Eur.J.Pharmacol., 1990;181:289 -
Vanilloids. 1. Analogs of capsaicin with antinociceptive and antiinflammatory activity.
Janusz et al.
J.Med.Chem., 1993;36:2595 -
Cannabinoid activation of recombinant and endogenous vanilloid receptors.
Ralevic et al.
Eur.J.Pharmacol., 2001;424:211
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for Olvanil
The citations listed below are publications that use Tocris products. Selected citations for Olvanil include:
1 Citation: Showing 1 - 1
-
Use of a fluorescent imaging plate reader--based calcium assay to assess pharmacological differences between the human and rat vanilloid receptor.
Authors: Witte Et al.
Am J Physiol Endocrinol Metab 2002;7:466
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Olvanil
There are currently no reviews for this product. Be the first to review Olvanil and earn rewards!
Have you used Olvanil?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image