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ONO 6818

Catalog #: 5651 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5651/10
ONO 6818 | CAS No. 208848-19-5 | Synthetic Elastase Inhibitors
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Description: High affinity and selective human neutrophil elastase 1 (HNE1) inhibitor; orally active

Chemical Name: 5-Amino-N-[1-[[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-methylpropyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetamide

Purity: ≥98%

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Biological Activity

ONO 6818 is a high affinity and selective human neutrophil elastase 1 (HNE1) inhibitor (Ki = 12 nM). Exhibits >100-fold less activity at other related proteases including trypsin, pancreatic elastase, collagenase and murine macrophage elastase. Inhibits HNE-induced lung hemorrhaging and suppresses leukocyte levels in an in vivo model of COPD. Orally active.

Technical Data

M.Wt:
452.51
Formula:
C23H28N6O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
208848-19-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters.
    Hirota et al.
    J.Vet.Med.Sci., 2004;66:1223
  2. Serine proteases increase oxidative stress in lung cells.
    Aoshiba et al.
    Am.J.Physiol.Lung Cell Mol.Physiol., 2001;281:556
  3. AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase.
    Stevens et al.
    J.Pharmacol.Exp.Ther., 2011;339:313

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