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Ononetin

Catalog #: 5143
1 Citation Datasheet / COA / SDS
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5143/50
Ononetin | CAS No. 487-49-0 | TRPM Blockers
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Description: TRPM3 blocker

Chemical Name: 1-(2,4-Dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Ononetin is a naturally occurring deoxybenzoin. TRPM3 channel blocker (IC50 = 300 nM). Inhibits pregnenolone sulfate-induced intracellular Ca2+ accumulation in HEKmTRPM3 cells and dorsal root ganglia (DRG) neurons in vitro.

Technical Data

M.Wt:
258.27
Formula:
C15H14O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
487-49-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3.
    Straub et al.
    Br.J.Pharmacol., 2012;168:1835

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Citation for Ononetin

The citations listed below are publications that use Tocris products. Selected citations for Ononetin include:

1 Citation: Showing 1 - 1

  1. Hypotonic stress induces RANKL via transient receptor potential melastatin 3 (TRPM3) and vaniloid 4 (TRPV4) in human PDL cells.
    Authors: Son Et al.
    J Dent Res  2015;94:473

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