Ouabain

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. Prolonged Intracellular Na+ Dynamics Govern Electrical Activity in Accessory Olfactory Bulb Mitral Cells.
   Zylbertal A, Kahan A, Ben-Shaul Y, Yarom Y, Wagner S
   PLoS Biol, 2016;13(12):e1002319.
3. Dietary Genistein Rescues Reduced Basal Chloride Secretion in Diabetic Jejunum via Sex-Dependent Mechanisms
   Layla Al-Nakkash
   Cell. Physiol. Biochem., 2016;40(2):335-346.
4. Diuretic sensitive electroneutral Na(+) movement and temperature effects on central axons
   M Kanagaratn, C Pendleton, DA Souza, J Pettit, J Howells, MD Baker
   J. Physiol. (Lond.), 2017;0(0):.
5. Extensive random mutagenesis analysis of the Na/K⁺ ATPase alpha subunit identifies known and previously unidentified amino acid residues that alter ouabain sensitivity-implications for ouabain binding.
   Croyle et al.
   Eur.J.Biochem., 1997;248:488
6. Isoform-specific up-regulation by ouabain of Na⁺, K⁺-ATPase in cultured rat astrocytes.
   Hosoi et al.
   J.Neurochem., 1997;69:2189
7. Ouabain improves cardiac function in vivo in rats with heart failure after chronic but not acute treatment.
   Marjorie et al.
   Naunyn Schmiedebergs Arch.Pharmacol., 1997;356:203
8. Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19.
   Ko et al.
   BioRxiv - Paper not yet peer reviewed, 2020;

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