PA 452
Chemical Name: 2-[[3-(Hexyloxy)-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl]methylamino]-5-pyrimidinecarboxylic acid
Purity: ≥98%
Biological Activity
PA 452 is an RXR antagonist (pA2 = 7.11). Triggers dissociation of RXR tetramers. Attenuates cell proliferation and induces apoptosis in MCF-7 breast cancer cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Customers also Viewed
Background References
-
Inhibition of mammary carcinoma cell growth by RXR is mediated by the receptor's oligomeric switch.
Yasmin et al.
J.Mol.Biol., 2010;397:1121 -
Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimer actions.
Takahashi et al.
J.Med.Chem., 2002;45:3327 -
Discovery of a potent retinoid X receptor antagonist structurally closely related to RXR agonist NEt-3IBIB.
Nakayama et al.
J.Med.Chem.Lett, 2011;2:896
Product Datasheets
Citations for PA 452
The citations listed below are publications that use Tocris products. Selected citations for PA 452 include:
2 Citations: Showing 1 - 2
-
A Chimeric Humanized Mouse Model by Engrafting the Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cell for the Chronic Hepatitis B Virus Infection.
Authors: Yuan Et al.
Front Microbiol 2018;9:908
-
Retinoic acid inhibits white adipogenesis by disrupting GADD45A-mediated Zfp423 DNA demethylation.
Authors: Wang Et al.
J Mol Cell Biol 2017;9:338
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for PA 452
There are currently no reviews for this product. Be the first to review PA 452 and earn rewards!
Have you used PA 452?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
