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Pan Caspase Inhibitor Z-VAD-FMK

Catalog #: FMK001
214 Citations 3 Reviews Datasheet / COA / SDS
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FMK001
Product Details
Citations (214)
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Reviews (3)
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Pan Caspase Inhibitor Z-VAD-FMK Summary

 

Key Benefits

Cell permeable fluoromethyl ketone (FMK)-derivatized peptides act as effective irreversible Caspase inhibitors with no cytotoxic effects and, therefore, are useful tools for studying Caspase activity.

Specifications

Source
N/A
Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Multi-Species

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Citations for Pan Caspase Inhibitor Z-VAD-FMK

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

214 Citations: Showing 1 - 10
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  1. Astrocytes and the tumor microenvironment inflammatory state dictate the killing of glioblastoma cells by Smac mimetic compounds
    Authors: Malone, K;Dugas, M;Earl, N;Alain, T;LaCasse, EC;Beug, ST;
    Cell death & disease  2024-08-15
  2. Necrosis drives susceptibility to Mycobacterium tuberculosis in POLG mtDNA mutator mice
    Authors: Mabry, CJ;Weindel, CG;Stranahan, LW;Martinez, EL;VanPortfliet, JJ;West, AP;Patrick, KL;Watson, RO;
    bioRxiv : the preprint server for biology  2024-07-22
  3. Ibulocydine Inhibits Migration and Invasion of TNBC Cells via MMP-9 Regulation.
    Authors: Kwon, MR;Park, JS;Ko, EJ;Park, J;Ju, EJ;Shin, SH;Son, GW;Lee, HW;Park, YY;Kang, MH;Kim, YJ;Kim, BM;Lee, HJ;Kim, TW;Kim, CJ;Song, SY;Park, SS;Jeong, SY;
    International journal of molecular sciences  2024-06-01
  4. EGFR inhibits TNF-?-mediated pathway by phosphorylating TNFR1 at tyrosine 360 and 401
    Authors: Nam, YW;Shin, JH;Kim, S;Hwang, CH;Lee, CS;Hwang, G;Kim, HR;Roe, JS;Song, J;
    Cell death and differentiation  2024-05-24
  5. Ionizable Lipid Nanoparticle-Mediated TRAIL mRNA Delivery in the Tumor Microenvironment to Inhibit Colon Cancer Progression
    Authors: da Silva, WN;Carvalho Costa, PA;Scalzo Júnior, SRA;Ferreira, HAS;Prazeres, PHDM;Campos, CLV;Rodrigues Alves, MT;Alves da Silva, NJ;de Castro Santos, AL;Guimarães, LC;Chen Ferris, ME;Thatte, A;Hamilton, A;Bicalho, KA;Lobo, AO;Santiago, HDC;da Silva Barcelos, L;Figueiredo, MM;Teixeira, MM;Vasconcelos Costa, V;Mitchell, MJ;Frézard, F;Pires Goulart Guimaraes, P;
    International journal of nanomedicine  2024-03-14
  6. Rotundifuran Induces Ferroptotic Cell Death and Mitochondria Permeability Transition in Lung Cancer Cells
    Authors: Kang, MJ;Moon, DO;Park, JY;Kim, N;Lee, SH;Ryu, HW;Huh, YH;Lee, HS;Kim, MO;
    Biomedicines  2024-03-05
  7. Caloric restriction leads to druggable LSD1-dependent cancer stem cells expansion
    Authors: Pallavi, R;Gatti, E;Durfort, T;Stendardo, M;Ravasio, R;Leonardi, T;Falvo, P;Duso, BA;Punzi, S;Xieraili, A;Polazzi, A;Verrelli, D;Trastulli, D;Ronzoni, S;Frascolla, S;Perticari, G;Elgendy, M;Varasi, M;Colombo, E;Giorgio, M;Lanfrancone, L;Minucci, S;Mazzarella, L;Pelicci, PG;
    Nature communications  2024-01-27
  8. Caspase inhibition improves viability and efficiency of liposomal transfection
    Authors: Yoshida, T;Yamasaki, K;Tadagaki, K;
    Scientific reports  2023-12-10
  9. SIRT1 regulates hepatocyte programmed cell death via GSDME - IL18 axis in human and mouse liver transplantation
    Authors: Kadono, K;Kojima, H;Yao, S;Kageyama, S;Nakamura, K;Hirao, H;Ito, T;Dery, KJ;Farmer, DG;Kaldas, FM;Li, X;Kupiec-Weglinski, JW;
    Cell death & disease  2023-11-23
  10. Insulin-like Growth Factor II mRNA-Binding Protein 1 Regulates Pancreatic Cancer Cell Growth through the Surveillance of CDC25A mRNA
    Authors: Di Fusco, D;Segreto, MT;Di Maggio, G;Iannucci, A;Maresca, C;Di Grazia, A;Colella, M;Stolfi, C;Monteleone, G;Monteleone, I;
    Cancers  2023-10-13
  11. The Biological Action and Structural Characterization of Eryngitin 3 and 4, Ribotoxin-like Proteins from Pleurotus eryngii Fruiting Bodies
    Authors: Ragucci, S;Landi, N;Citores, L;Iglesias, R;Russo, R;Clemente, A;Saviano, M;Pedone, PV;Chambery, A;Ferreras, JM;Di Maro, A;
    International journal of molecular sciences  2023-09-22
  12. KMU-191 Induces Apoptosis in Human Clear Cell Renal Cell Carcinoma Caki Cells Through Modulation of Bcl-xL, Mcl-1 (L), c-FLIP (L), and p53 Proteins
    Authors: Kim, S;Kim, DE;Kang, H;Hong, VS;Jeon, J;Lee, J;Kim, KS;Park, JW;
    Journal of Cancer  2023-07-16
  13. SIRT1 Regulates Hepatocyte Programmed Cell Death via GSDME - IL18 Axis in Human and Mouse Liver Transplantation
    Authors: Kadono, K;Kojima, H;Yao, S;Kageyama, S;Nakamura, K;Hirao, H;Ito, T;Dery, K;Farmer, D;Kaldas, F;Li, X;Kupiec-Weglinski, J;
    Research square  2023-06-27
  14. Necroptosis Induced by Delta-Tocotrienol Overcomes Docetaxel Chemoresistance in Prostate Cancer Cells
    Authors: M Montagnani, G Beretta, RM Moretti
    International Journal of Molecular Sciences, 2023-03-03;24(5):.  2023-03-03
  15. Mechanism of cis-Nerolidol-Induced Bladder Carcinoma Cell Death
    Authors: M Glumac, V ?ikeš ?uli, I Marinovi?-, M Radan
    Cancers, 2023-02-03;15(3):.  2023-02-03
  16. Dual inhibition of thioredoxin reductase and proteasome is required for auranofin-induced paraptosis in breast cancer cells
    Authors: MJ Seo, IY Kim, DM Lee, YJ Park, MY Cho, HJ Jin, KS Choi
    Cell Death & Disease, 2023-01-19;14(1):42.  2023-01-19
  17. Libertellenone T, a Novel Compound Isolated from Endolichenic Fungus, Induces G2/M Phase Arrest, Apoptosis, and Autophagy by Activating the ROS/JNK Pathway in Colorectal Cancer Cells
    Authors: CDB Gamage, JH Kim, Y Yang, ? Ta?, SY Park, R Zhou, S Pulat, M Varl?, JS Hur, SJ Nam, H Kim
    Cancers, 2023-01-12;15(2):.  2023-01-12
  18. Galectin-9 has non-apoptotic cytotoxic activity towards Acute Myeloid Leukemia independent of cytarabine resistance
    Authors: Wiersma, V;Choukrani, G;Visser, N;Avtenyuk, N;Olthuis, M;Marsman, G;Ammatuna, E;Lourens, H;Niki, T;Huls, G;Bremer, E;
    Research Square  2023-01-01
  19. JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation
    Authors: G Lee, H Ahn, JH Yun, J Park, E Lee, S Oh, GS Lee
    Scientific Reports, 2022-12-28;12(1):22484.  2022-12-28
  20. AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology
    Authors: L Tilokani, FM Russell, S Hamilton, DM Virga, M Segawa, V Paupe, AV Gruszczyk, M Protasoni, LC Tabara, M Johnson, H Anand, MP Murphy, DG Hardie, F Polleux, J Prudent
    Science Advances, 2022-11-11;8(45):eabo7956.  2022-11-11
  21. TRAF3/p38-JNK Signalling Crosstalk with Intracellular-TRAIL/Caspase-10-Induced Apoptosis Accelerates ROS-Driven Cancer Cell-Specific Death by CD40
    Authors: K Ibraheem, AMA Yhmed, MM Nasef, NT Georgopoul
    Cells, 2022-10-18;11(20):.  2022-10-18
  22. Vitamin C Suppresses Pancreatic Carcinogenesis through the Inhibition of Both Glucose Metabolism and Wnt Signaling
    Authors: JH Kim, S Hwang, JH Lee, SS Im, J Son
    International Journal of Molecular Sciences, 2022-10-14;23(20):.  2022-10-14
  23. Inhibition of USP1 enhances anticancer drugs-induced cancer cell death through downregulation of survivin and miR-216a-5p-mediated upregulation of DR5
    Authors: SM Woo, S Kim, SU Seo, S Kim, JW Park, G Kim, YR Choi, K Hur, TK Kwon
    Cell Death & Disease, 2022-09-24;13(9):821.  2022-09-24
  24. DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells
    Authors: YS Michaels, JM Edgar, MC Major, EL Castle, C Zimmerman, T Yin, A Hagner, C Lau, HH Hsu, MI Ibañez-Rio, LJ Durland, DJHF Knapp, PW Zandstra
    Science Advances, 2022-08-24;8(34):eabn5522.  2022-08-24
  25. Isolation, Characterization and Biological Action of Type-1 Ribosome-Inactivating Proteins from Tissues of Salsola soda L
    Authors: N Landi, S Ragucci, L Citores, A Clemente, HZF Hussain, R Iglesias, JM Ferreras, A Di Maro
    Toxins, 2022-08-19;14(8):.  2022-08-19
  26. Magmas Inhibition in Prostate Cancer: A Novel Target for Treatment-Resistant Disease
    Authors: J Yang, BC Das, O Aljitawi, A Kumar, S Das, P Van Veldhu
    Cancers, 2022-05-31;14(11):.  2022-05-31
  27. Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations
    Authors: CR Bell, VS Pelly, A Moeini, SC Chiang, E Flanagan, CP Bromley, C Clark, CH Earnshaw, MA Koufaki, E Bonavita, S Zelenay
    Nature Communications, 2022-04-19;13(1):2063.  2022-04-19
  28. Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes
    Authors: D Beillevair, F Migneault, J Turgeon, D Gingras, AK Rimbaud, G Marcoux, C Spino, N Thibodeau, E Bonneil, P Thibault, É Boilard, M Dieudé, MJ Hébert
    Cell Death & Disease, 2022-02-11;13(2):145.  2022-02-11
  29. Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis
    Authors: W Deng, Y Bai, F Deng, Y Pan, S Mei, Z Zheng, R Min, Z Wu, W Li, R Miao, Z Zhang, TS Kupper, J Lieberman, X Liu
    Nature, 2022-02-02;0(0):.  2022-02-02
  30. FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury
    Authors: B Lee, Y Oh, E Cho, A DiAntonio, V Cavalli, JE Shin, HW Choi, Y Cho
    The Journal of Biological Chemistry, 2022-01-29;0(0):101647.  2022-01-29
  31. Galectin-9 Triggers Neutrophil-Mediated Anticancer Immunity
    Authors: N Ustyanovsk, G Choukrani, E Ammatuna, T Niki, E Cendrowicz, HJ Lourens, G Huls, VR Wiersma, E Bremer
    Biomedicines, 2021-12-29;10(1):.  2021-12-29
  32. Lucanthone, Autophagy Inhibitor, Enhances the Apoptotic Effects of TRAIL through miR-216a-5p-Mediated DR5 Upregulation and DUB3-Mediated Mcl-1 Downregulation
    Authors: JY Yoon, SM Woo, SU Seo, SR Song, SG Lee, TK Kwon
    International Journal of Molecular Sciences, 2021-12-21;23(1):.  2021-12-21
  33. Apigenin Induces Autophagy and Cell Death by Targeting EZH2 under Hypoxia Conditions in Gastric Cancer Cells
    Authors: TW Kim, HG Lee
    International Journal of Molecular Sciences, 2021-12-15;22(24):.  2021-12-15
  34. AKF-D52, a Synthetic Phenoxypyrimidine-Urea Derivative, Triggers Extrinsic/Intrinsic Apoptosis and Cytoprotective Autophagy in Human Non-Small Cell Lung Cancer Cells
    Authors: HS Gil, JH Lee, AK Farag, AHE Hassan, KS Chung, JH Choi, EJ Roh, KT Lee
    Oncogene, 2021-11-22;13(22):.  2021-11-22
  35. LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy
    Authors: P Li, Q Li, N Biswas, H Xin, T Diemer, L Liu, L Perez Guti, G Paternostr, C Piermarocc, S Domanskyi, RK Wang, N Ferrara
    Embo Molecular Medicine, 2021-11-15;0(0):e14511.  2021-11-15
  36. Apoptosis Enhances the Replication of Human Coronavirus OC43
    Authors: S Maharjan, M Kang, J Kim, D Kim, S Park, M Kim, K Baek, Y Lee, HJ Kwon
    Viruses, 2021-11-01;13(11):.  2021-11-01
  37. Species-Specific Inhibition of Necroptosis by HCMV UL36
    Authors: E Muscolino, C Castiglion, R Brixel, G Frascaroli, W Brune
    Viruses, 2021-10-22;13(11):.  2021-10-22
  38. PI3Kdelta coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T�cells at the expense of central memory
    Authors: JL Cannons, AV Villarino, SM Kapnick, S Preite, HY Shih, J Gomez-Rodr, Z Kaul, H Shibata, JM Reilley, B Huang, R Handon, IT McBain, S Gossa, T Wu, HC Su, DB McGavern, JJ O'Shea, PJ McGuire, G Uzel, PL Schwartzbe
    Cell Reports, 2021-10-12;37(2):109804.  2021-10-12
  39. Charting the N-Terminal Acetylome: A Comprehensive Map of Human NatA Substrates
    Authors: P Van Damme
    International Journal of Molecular Sciences, 2021-10-02;22(19):.  2021-10-02
  40. Parabens disrupt non-canonical inflammasome activation
    Authors: H Ahn, H Lee, G Lee, J Park, HW Sung, E Lee, GS Lee
    International immunopharmacology, 2021-09-30;101(0):108196.  2021-09-30
  41. Caspase-Dependent HMGB1 Release from Macrophages Participates in Peripheral Neuropathy Caused by Bortezomib, a Proteasome-Inhibiting Chemotherapeutic Agent, in Mice
    Authors: M Tsubota, T Miyazaki, Y Ikeda, Y Hayashi, Y Aokiba, S Tomita, F Sekiguchi, D Wang, M Nishibori, A Kawabata
    Cells, 2021-09-27;10(10):.  2021-09-27
  42. Inhibition of BMI-1 Induces Apoptosis through Downregulation of DUB3-Mediated Mcl-1 Stabilization
    Authors: K Wu, SM Woo, SU Seo, TK Kwon
    International Journal of Molecular Sciences, 2021-09-18;22(18):.  2021-09-18
  43. Selenium-GPX4 axis protects follicular helper T cells from ferroptosis
    Authors: Y Yao, Z Chen, H Zhang, C Chen, M Zeng, J Yunis, Y Wei, Y Wan, N Wang, M Zhou, C Qiu, Q Zeng, HS Ong, H Wang, FV Makota, Y Yang, Z Yang, N Wang, J Deng, C Shen, Y Xia, L Yuan, Z Lian, Y Deng, C Guo, A Huang, P Zhou, H Shi, W Zhang, H Yi, D Li, M Xia, J Fu, N Wu, JB de Haan, N Shen, W Zhang, Z Liu, D Yu
    Nature Immunology, 2021-08-19;22(9):1127-1139.  2021-08-19
  44. Synergistic Antitumor Activity of SH003 and Docetaxel via EGFR Signaling Inhibition in Non-Small Cell Lung Cancer
    Authors: MS Jeong, KW Lee, YJ Choi, YG Kim, HH Hwang, SY Lee, SE Jung, SA Park, JH Lee, YJ Joo, SG Cho, SG Ko
    International Journal of Molecular Sciences, 2021-08-05;22(16):.  2021-08-05
  45. The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output
    Authors: DC Kanellis, JA Espinoza, A Zisi, E Sakkas, J Bartkova, AM Katsori, J Boström, L Dyrskjøt, H Broholm, M Altun, SJ Elsässer, MS Lindström, J Bartek
    Science Advances, 2021-08-04;7(32):.  2021-08-04
  46. N-3-Hydroxy Dodecanoyl-DL-homoserine Lactone (OH-dDHL) Triggers Apoptosis of Bone Marrow-Derived Macrophages through the ER- and Mitochondria-Mediated Pathways
    Authors: K Woo, DH Kim, MH Oh, HS Park, CH Choi
    International Journal of Molecular Sciences, 2021-07-15;22(14):.  2021-07-15
  47. 3-Methyladenine prevents energy stress-induced necrotic death of melanoma cells through autophagy-independent mechanisms
    Authors: M Kosic, V Paunovic, B Ristic, A Mircic, M Bosnjak, D Stevanovic, T Kravic-Ste, V Trajkovic, L Harhaji-Tr
    Journal of pharmacological sciences, 2021-06-11;147(1):156-167.  2021-06-11
  48. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer
    Authors: C Mao, X Liu, Y Zhang, G Lei, Y Yan, H Lee, P Koppula, S Wu, L Zhuang, B Fang, MV Poyurovsky, K Olszewski, B Gan
    Nature, 2021-05-12;0(0):.  2021-05-12
  49. Characterization of HIV-induced remodeling reveals differences in infection susceptibility of memory CD4+ T�cell subsets in�vivo
    Authors: G Xie, X Luo, T Ma, J Frouard, J Neidleman, R Hoh, SG Deeks, WC Greene, NR Roan
    Cell Reports, 2021-04-27;35(4):109038.  2021-04-27
  50. Netrin-1 receptor UNC5C cleavage by active &delta-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies
    Authors: G Chen, SS Kang, Z Wang, EH Ahn, Y Xia, X Liu, IM Sandoval, FP Manfredsso, Z Zhang, K Ye
    Science Advances, 2021-04-16;7(16):.  2021-04-16
  51. Selective Anti-Cancer Effects of Plasma-Activated Medium and Its High Efficacy with Cisplatin on Hepatocellular Carcinoma with Cancer Stem Cell Characteristics
    Authors: Y Li, T Tang, HJ Lee, K Song
    International Journal of Molecular Sciences, 2021-04-12;22(8):.  2021-04-12
  52. ABT?737, a Bcl?2 family inhibitor, has a synergistic effect with apoptosis by inducing urothelial carcinoma cell necroptosis
    Authors: R Cheng, X Liu, Z Wang, K Tang
    Molecular Medicine Reports, 2021-03-31;23(6):.  2021-03-31
  53. Clustering of Tir during enteropathogenic E. coli infection triggers calcium influx-dependent pyroptosis in intestinal epithelial cells
    Authors: Q Zhong, TI Roumelioti, Z Kozik, M Cepeda-Mol, LÁ Fernández, AR Shenoy, C Bakal, G Frankel, JS Choudhary
    PloS Biology, 2020-12-30;18(12):e3000986.  2020-12-30
  54. Novel Small Molecular Compound AE-848 Potently Induces Human Multiple Myeloma Cell Apoptosis by Modulating the NF-&kappaB and PI3K/Akt/mTOR Signaling Pathways
    Authors: Y Xu, X Feng, Q Zhou, W Jiang, Y Dai, Y Jiang, X Liu, S Li, Y Wang, F Wang, A Li, C Zheng
    OncoTargets and Therapy, 2020-12-22;13(0):13063-13075.  2020-12-22
  55. Combined the SMAC mimetic and BCL2 inhibitor sensitizes neoadjuvant chemotherapy by targeting necrosome complexes in tyrosine aminoacyl-tRNA synthase-positive breast cancer
    Authors: KM Lee, H Lee, D Han, WK Moon, K Kim, HJ Oh, J Choi, EH Hwang, SE Kang, SA Im, KH Lee, HS Ryu
    Breast Cancer Res, 2020-11-25;22(1):130.  2020-11-25
  56. Induction of Lysosomal Membrane Permeabilization Is a Major Event of FTY720-Mediated Non-Apoptotic Cell Death in Human Glioma Cells
    Authors: KJ Min, TK Kwon
    Cancers (Basel), 2020-11-16;12(11):.  2020-11-16
  57. Synergistic apoptotic effects in cancer cells by the combination of CLK and Bcl-2 family inhibitors
    Authors: A Murai, S Ebara, S Sasaki, T Ohashi, T Miyazaki, T Nomura, S Araki
    PLoS ONE, 2020-10-16;15(10):e0240718.  2020-10-16
  58. Pharmacological Inhibition of WEE1 Potentiates the Antitumoral Effect of the dl922-947 Oncolytic Virus in Malignant Mesothelioma Cell Lines
    Authors: CA Iannuzzi, P Indovina, IM Forte, S Di Somma, AM Malfitano, M Bruno, G Portella, F Pentimalli, A Giordano
    Int J Mol Sci, 2020-10-04;21(19):.  2020-10-04
  59. The Pseudomonas aeruginosa protease LasB directly activates IL-1&beta
    Authors: J Sun, DL LaRock, EA Skowronski, JM Kimmey, J Olson, Z Jiang, AJ O'Donoghue, V Nizet, CN LaRock
    EBioMedicine, 2020-09-23;60(0):102984.  2020-09-23
  60. Reduction in MLKL-mediated endosomal trafficking enhances the TRAIL-DR4/5 signal to increase cancer cell death
    Authors: SY Park, HH Park, SY Park, SM Hong, S Yoon, MJ Morgan, YS Kim
    Cell Death Dis, 2020-09-11;11(9):744.  2020-09-11
  61. Cryptotanshinone chemosensitivity potentiation by TW-37 in human oral cancer cell lines by targeting STAT3-Mcl-1 signaling
    Authors: IH Yang, SH Hong, M Jung, CH Ahn, HJ Yoon, SD Hong, SD Cho, JA Shin
    Cancer Cell Int., 2020-08-26;20(0):405.  2020-08-26
  62. Upregulation of DR5 and Downregulation of Survivin by IITZ-01, Lysosomotropic Autophagy Inhibitor, Potentiates TRAIL-Mediated Apoptosis in Renal Cancer Cells via Ubiquitin-Proteasome Pathway
    Authors: SA Shahriyar, SU Seo, KJ Min, P Kubatka, DS Min, JS Chang, DE Kim, SM Woo, TK Kwon
    Cancers (Basel), 2020-08-21;12(9):.  2020-08-21
  63. Involvement of the NF-&kappaB signaling pathway in proliferation and invasion inhibited by Zwint-1 deficiency in Pancreatic Cancer Cells
    Authors: JH Kim, Y Youn, JC Lee, J Kim, JH Hwang
    Journal of Cancer, 2020-07-25;11(19):5601-5611.  2020-07-25
  64. Skp2 depletion reduces tumor-initiating properties and promotes apoptosis in synovial sarcoma
    Authors: J Wang, K Sato, E O'Donnell, A Singla, S Yaguare, O Aldahamshe, B Batko, H Borjihan, J Tingling, J Zhang, DA Weiser, DM Loeb, R Gorlick, EL Schwartz, R Yang, X Zi, H Zhao, DS Geller, BH Hoang
    Transl Oncol, 2020-07-02;13(10):100809.  2020-07-02
  65. Dual role of phosphatidylserine and its receptors in osteoclastogenesis
    Authors: JH Kang, HM Ko, GD Han, SY Lee, JS Moon, MS Kim, JT Koh, SH Kim
    Cell Death Dis, 2020-07-01;11(7):497.  2020-07-01
  66. Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid beta-Protein-Induced Synapse Loss in Alzheimer's Disease
    Authors: G Park, HS Nhan, SH Tyan, Y Kawakatsu, C Zhang, M Navarro, EH Koo
    Cell Rep, 2020-06-30;31(13):107839.  2020-06-30
  67. Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and beta-catenin induction in mesothelium
    Authors: F Ito, I Yanatori, Y Maeda, K Nimura, S Ito, T Hirayama, H Nagasawa, N Kohyama, Y Okazaki, S Akatsuka, S Toyokuni
    Redox Biol, 2020-06-24;36(0):101616.  2020-06-24
  68. Chrysophanol Regulates Cell Death, Metastasis, and Reactive Oxygen Species Production in Oral Cancer Cell Lines
    Authors: PC Hsu, CF Cheng, PC Hsieh, YH Chen, CY Kuo, HK Sytwu
    Evid Based Complement Alternat Med, 2020-05-26;2020(0):5867064.  2020-05-26
  69. Monoglyceride lipase mediates tumor-suppressive effects by promoting degradation of X-linked inhibitor of apoptosis protein
    Authors: R Liu, X Wang, C Curtiss, MS Sheikh, Y Huang
    Cell Death Differ., 2020-05-06;0(0):.  2020-05-06
  70. Osteogenic impact of pro-apoptotic caspase inhibitors in MC3T3-E1 cells
    Authors: A Kratochvíl, B Veselá, V Ledvina, E Švandová, K Klepárník, K Dadáková, P Beneš, E Matalová
    Sci Rep, 2020-05-04;10(1):7489.  2020-05-04
  71. PERK/NRF2 and autophagy form a resistance mechanism against G9a inhibition in leukemia stem cells
    Authors: JE Jang, JI Eom, HK Jeung, H Chung, YR Kim, JS Kim, JW Cheong, YH Min
    J. Exp. Clin. Cancer Res., 2020-04-15;39(1):66.  2020-04-15
  72. Combination of Arsenic Trioxide and Valproic Acid Efficiently Inhibits Growth of Lung Cancer Cells via G2/M-Phase Arrest and Apoptotic Cell Death
    Authors: HK Park, BR Han, WH Park
    Int J Mol Sci, 2020-04-10;21(7):.  2020-04-10
  73. Activation of JNK signaling promotes all-trans retinal-induced photoreceptor apoptosis in mice
    Authors: C Liao, B Cai, Y Feng, J Chen, Y Wu, J Zhuang, Z Liu, Y Wu
    J. Biol. Chem., 2020-04-07;0(0):.  2020-04-07
  74. Energy-stress-mediated AMPK activation inhibits ferroptosis
    Authors: H Lee, F Zandkarimi, Y Zhang, JK Meena, J Kim, L Zhuang, S Tyagi, L Ma, TF Westbrook, GR Steinberg, D Nakada, BR Stockwell, B Gan
    Nat. Cell Biol., 2020-02-06;22(2):225-234.  2020-02-06
  75. BAD sensitizes breast cancer cells to docetaxel with increased mitotic arrest and necroptosis
    Authors: J Mann, N Yang, R Montpetit, R Kirschenma, H Lemieux, IS Goping
    Sci Rep, 2020-01-15;10(1):355.  2020-01-15
  76. Regulation of Eosinophil Recruitment and Allergic Airway Inflammation by Tropomyosin Receptor Kinase A
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    J. Immunol., 2019-12-23;0(0):.  2019-12-23
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FAQs

  1. Does R&D Systems offer a negative control for Caspase Inihibitors with benzyloxycarbonyl group (Z-) at the N-terminus and the FMK functional group at the C-terminus?

    • Yes, R&D Systems offers Caspase Inhibitor Control Z-FA-FMK, Catalog # FMKC01, which is an inhibitor of cathepsins B and L but not caspases, and has been used in several systems as a negative control for peptide inhibitors of caspases.

  2. Are R&D Systems Caspase Inhibitors irreversible?

    • Yes, the majority of R&D Systems Caspase Inhibitors have a Fluoromethyl ketone (FMK) functional group on the C-terminus of the peptide, and act as effective irreversible inhibitors with no added cytotoxic effects. Inhibitors synthesized with a benzyloxycarbonyl group (also known as BOC or Z) at the N-terminus and O-methyl side chains exhibit enhanced cellular permeability.

      R&D Systems also offers a General Caspase Inhibitor, Q-VD-OPh, Catalog # OPH001, as well as a FITC-conjugated pan-caspase inhibitor (ApoStat), Catalog # FMK012, which are both cell-permeable, irreversible inhibitors of caspase activity.

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Pan Caspase Inhibitor Z-VAD-FMK
By Anonymous on 11/20/2020
Pan Caspase Inhibitor Z-VAD-FMK
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Pan Caspase Inhibitor Z-VAD-FMK
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M30 CytoDEATH in vitro staining of apoptosis induced by hydrogen peroxide.

Pan Caspase Inhibitor Z-VAD-FMK FMK001