Parameter Immunoassay Control Set 870 for cGMP
Parameter Immunoassay Control Set 870 for cGMP Summary
INTENDED USE & DESCRIPTION
For use as quantitative controls for the determination of cytokine concentrations in biological fluids. Concentrations have been assigned using R&D Systems’ Parameter® kits. Controls are prepared in diluted porcine serum with preservatives. They contain recombinant human cytokines at low, medium and high concentrations. Controls are supplied lyophilized.
STORAGE & STABILITY
Unreconstituted Controls should be stored at 2-8 °C and are stable for at least 6 months from date of receipt. Depending on the analyte of interest, reconstituted controls may be stable when stored at < -20 °C. Users should evaluate the frozen stability of the controls in their application or discard after use.
REAGENT PREPARATION
Reconstitute each vial with the volume of deionized or distilled water indicated on the product datasheet.
PROCEDURE & EXPECTED VALUES
Controls should be assayed in the same manner as unknown specimens.
The acceptable ranges for the analytes in these controls are printed on the product datasheet. Due to possible variations in techniques and methodologies, it is recommended that each laboratory determine its own target range. Laboratories using other test systems should establish their own acceptable ranges as these assays may produce different values.
TECHNICAL HINTS & LIMITATIONS OF THE PROCEDURE
• The ranges were determined using R&D Systems’ Parameter kits. If expected values are not obtained, verify that the lot numbers on the vials correspond with the lot numbers listed above and the correct volume of deionized or distilled water was used for reconstitution of the controls.
• The results obtained with these controls depend upon several factors associated with methods and instrumentation. Test systems other than those supplied by R&D Systems may result in values that differ from those printed on this product datasheet.
Specifications
Background: cGMP
Guanosine 3, 5-cyclic monophosphate (cGMP) is formed via the action of guanylate cyclase on GTP. cGMP is present at levels typically 10-100 fold lower than cAMP in most tissues. A variety of stimuli including acetylcholine, insulin, oxytocin, serotonin, and histamine will cause an increase in cGMP levels. Various stimulators of guanylate cyclase (e.g. vasodilators) as well as peptides that relax smooth muscle also increase cGMP concentrations.
Citations for Parameter Immunoassay Control Set 870 for cGMP
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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A randomised placebo controlled trial of VSL#3� probiotic on biomarkers of cardiovascular risk and liver injury in non-alcoholic fatty liver disease
Authors: PL Chong, D Laight, RJ Aspinall, A Higginson, MH Cummings
BMC gastroenterology, 2021-04-01;21(1):144. 2021-04-01
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Natriuretic Peptide Expression and Function in GH3 Somatolactotropes and Feline Somatotrope Pituitary Tumours
Authors: SM Mirczuk, CJ Scudder, JE Read, VJ Crossley, JT Regan, KM Richardson, B Simbi, CA McArdle, DB Church, J Fenn, PJ Kenny, HA Volk, CP Wheeler-Jo, M Korbonits, SJ Niessen, IM McGonnell, RC Fowkes
International Journal of Molecular Sciences, 2021-01-22;22(3):. 2021-01-22
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Cardiorenal and endocrine effects of synthetic canine BNP1-32 in dogs with compensated congestive heart failure caused by myxomatous mitral valve disease
Authors: M Yata, HS Kooistra, NJ Beijerink
J. Vet. Intern. Med., 2019-01-31;0(0):. 2019-01-31
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